Khan S A, Brennan P, Newman J, Gray R E, McCloskey E V, Kanis J A
WHO Collaborating Centre for Metabolic Bone Disease, Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, UK.
Bone. 1996 Jul;19(1):47-50. doi: 10.1016/8756-3282(96)00117-2.
The etiology of Paget's disease is unknown, but several observations suggest a viral cause. Since canine distemper virus is among those proposed to be a causal agent, we investigated the hypothesis that dog ownership may increase the risk of Paget's disease of bone by means of a case control study. One hundred and fifty patients with Paget's disease and 185 controls were interviewed using a structured questionnaire administered by the same interviewer. Participants were asked about their socioeconomic background and their exposure to pets. The risk of Paget's disease was not significantly increased in individuals. However, ownership of a mongrel dog was associated with a significant increase in risk (OR = 1.6; 95% CI = 1.0-2.4) and the risk increased still further with the ownership of an unvaccinated dog (OR = 2.8; 95% CI = 1.8-4.5). Additionally, ownership of cats and birds excluding dog owners, increased the risk of Paget's disease (OR = 2.5; 95% CI = 1.0-5.0; OR = 2.3; 95% CI = 1.0-5.3, respectively). These data suggest that previous exposure to cats, birds, and dogs unvaccinated for canine distemper may increase the risk of an individual developing Paget's disease of bone.
佩吉特病的病因尚不清楚，但一些观察结果提示可能由病毒引起。由于犬瘟热病毒是被认为可能的致病因素之一，我们通过一项病例对照研究调查了养狗是否会增加患骨佩吉特病的风险这一假设。由同一名访谈者使用结构化问卷对150例佩吉特病患者和185名对照进行了访谈。询问了参与者的社会经济背景以及他们与宠物的接触情况。佩吉特病的风险在个体中并未显著增加。然而，养杂种狗与风险显著增加相关（比值比=1.6；95%置信区间=1.0-2.4），而养未接种疫苗的狗风险进一步增加（比值比=2.8；95%置信区间=1.8-4.5）。此外，养猫和养鸟（不包括养狗者）会增加患佩吉特病的风险（比值比分别为2.5；95%置信区间=1.0-5.0；比值比=2.3；95%置信区间=1.0-5.3）。这些数据表明，既往接触猫、鸟以及未接种犬瘟热疫苗的狗可能会增加个体患骨佩吉特病的风险。
