Renier J C, Fanello S, Bos C, Audran M
Rheumatology Department, Angers Teaching Hospital, France.
Rev Rhum Engl Ed. 1996 Oct;63(9):606-11.
The objective of this case-control questionnaire study was to determine whether a history of measles or of dog ownership occurred with different frequencies in Paget's disease patients and in age- and sex-matched controls. Clustering of Paget's disease cases in geographic foci was also looked for, as well as a difference in the prevalence of Paget's disease according to whether the subsoil was composed of rocks from the primary or the tertiary-quaternary geologic periods. Completed questionnaires were obtained from 247 Paget's disease patients and 281 controls. Paget's disease was significantly associated with a history of measles (odds ratio, 2.46) but not with a history of mumps (odds ratio, 0.79) or with dog ownership (odds ratio, 0.97). The 174 cases of Paget's disease in subjects from the study district were distributed throughout the district, with no geographic clustering. This result was confirmed by the analysis of the ratios of Paget's disease cases over the total population in each county in the study district. The incidence of Paget's disease was slightly higher in areas with a primary subsoil, but the difference was not statistically significant (chi-square, 0.79; P = 0.37).
这项病例对照问卷调查研究的目的是确定佩吉特氏病患者以及年龄和性别匹配的对照组中，麻疹病史或养狗史的发生频率是否存在差异。同时，研究人员还探寻了佩吉特氏病病例在地理区域上的聚集情况，以及根据地下土壤是由原生地质时期还是第三纪 - 第四纪地质时期的岩石构成，佩吉特氏病患病率是否存在差异。研究人员从247名佩吉特氏病患者和281名对照者那里获取了完整的问卷。佩吉特氏病与麻疹病史显著相关（优势比为2.46），但与腮腺炎病史（优势比为0.79）或养狗史（优势比为0.97）无关。研究区域内的174例佩吉特氏病病例分布在整个区域，没有出现地理聚集现象。这一结果通过对研究区域内每个县的佩吉特氏病病例与总人口比例的分析得到了证实。在地下土壤为原生地质时期的地区，佩吉特氏病的发病率略高，但差异无统计学意义（卡方值为0.79；P = 0.37）。
