Vollmar A M, Montag C, Preusser U, Kraft W, Schulz R
Institute of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, University of Munich, Germany.
Zentralbl Veterinarmed A. 1994 Sep;41(7):548-57. doi: 10.1111/j.1439-0442.1994.tb00122.x.
Studies in humans and experimental animal models suggest that volume overload increases and volume underload decreases release of atrial natriuretic peptide (ANP), a hormone intimately linked to water and electrolyte homeostasis. This relationship was examined in dogs suffering from heart failure or dehydration and the data presented here are in support of this general concept. Plasma ANP concentration in dogs with congestive heart failure (CHF) was elevated with the severity of the disease (NYHA classification, class II: 21.4 +/- 9.2 fmol ANP/ml; class III: 65.5 +/- 72.6; class IV: 119.7 +/- 87.1; healthy dogs: 13.9 +/- 7.5). The increment in plasma ANP concentration in cardiac patients was also positively correlated with the plasma volume. The blood volume of dogs with moderate and severe CHF was significantly (P < 0.05) elevated and a normotonic blood pressure prevailed. In contrast, dehydrated dogs tend to display reduced ANP plasma concentration (7.7 +/- 5.6 fmol/ml) as well as significantly lower plasma volume and reduced blood pressure (P < 0.05). In dogs with severe CHF, ANP precursor material is present in the blood, which is normally undetectable. These data further support the concept of a regulatory function of ANP in volume homeostasis of dogs.
对人类和实验动物模型的研究表明，容量超负荷会增加心房利钠肽（ANP）的释放，而容量不足则会减少其释放，ANP是一种与水和电解质平衡密切相关的激素。在患有心力衰竭或脱水的犬类中研究了这种关系，此处呈现的数据支持这一普遍概念。患有充血性心力衰竭（CHF）的犬类血浆ANP浓度随疾病严重程度升高（纽约心脏协会分级，II级：21.4±9.2 fmol ANP/ml；III级：65.5±72.6；IV级：119.7±87.1；健康犬：13.9±7.5）。心脏病患者血浆ANP浓度的增加也与血浆容量呈正相关。中度和重度CHF犬的血容量显著升高（P<0.05），且维持正常渗透压血压。相比之下，脱水犬的ANP血浆浓度往往降低（7.7±5.6 fmol/ml），血浆容量和血压也显著降低（P<0.05）。在患有严重CHF的犬类中，血液中存在ANP前体物质，而在正常情况下无法检测到。这些数据进一步支持了ANP在犬类容量稳态中具有调节功能的概念。
