神经节苷脂（GM1）对衰老大鼠记忆力的影响。

Effect of ganglioside (GM1) on memory in senescent rats.

作者信息

Silva R H, Felicio L F, Nasello A G, Vital M A, Frussa-Filho R

机构信息

Departamento de Farmacologia, Escola Paulista de Medicina, São Paulo, Brasil.

出版信息

Neurobiol Aging. 1996 Jul-Aug;17(4):583-6. doi: 10.1016/0197-4580(96)00065-6.

DOI:10.1016/0197-4580(96)00065-6

PMID:8832633

Abstract

Monosialoganglioside GM1 (GM1) has been found to alleviate genetic and lesion-induced memory deficits. The purpose of this study was to investigate the effects of 7-day treatment with GM1 (50 mg/kg IP) on acquisition and retention performance of senescent rats in a passive avoidance situation. Saline-treated old rats showed a decreased performance in acquisition and retention tests as compared to saline-treated adult rats. GM1 improved both acquisition and retention performance of old animals, and there was no significant difference between GM1-treated old rats and saline-treated adult rats. These data suggest that GM1 treatment can improve memory deficits in intact senescent animals.

摘要

单唾液酸神经节苷脂GM1（GM1）已被发现可减轻遗传性和损伤性诱导的记忆缺陷。本研究的目的是调查GM1（50mg/kg腹腔注射）连续7天治疗对衰老大鼠在被动回避情境中获得和保持能力的影响。与生理盐水处理的成年大鼠相比，生理盐水处理的老年大鼠在获得和保持测试中的表现下降。GM1改善了老年动物的获得和保持能力，并且GM1处理的老年大鼠与生理盐水处理的成年大鼠之间没有显著差异。这些数据表明，GM1治疗可改善未受损衰老动物的记忆缺陷。