Chng H H, Leong K P, Loh K C
Department of Rheumatology, Tan Tock Seng Hospital, Singapore.
Allergy. 1995 Dec;50(12):984-7. doi: 10.1111/j.1398-9995.1995.tb02512.x.
Primary systemic allergy to human insulin is rare. We report a case of recurrent immediate local reactions followed eventually by generalized urticaria to recombinant human insulin (Humulin) in an insulin-dependent diabetic. Skin test to Humulin R was positive, and the patient was successfully desensitized using a modified rapid desensitization protocol. Two weeks later, he had another episode of generalized urticaria after Humulin R injection. His treatment was resumed at a lower dose, and within a week he was able to tolerate his usual regimen of insulin. To our knowledge, this is the first report of a recurrence of systemic reaction after successful desensitization.
原发性对人胰岛素过敏很少见。我们报告一例胰岛素依赖型糖尿病患者，反复出现即刻局部反应，最终对重组人胰岛素（优泌林）发生全身性荨麻疹。对优泌林R的皮肤试验呈阳性，使用改良的快速脱敏方案对该患者成功进行了脱敏治疗。两周后，他在注射优泌林R后又出现了一次全身性荨麻疹发作。以较低剂量恢复治疗，一周内他就能耐受其常规胰岛素治疗方案。据我们所知，这是成功脱敏后全身反应复发的首例报告。
