RPR 106972（一种新型口服链阳菌素）、头孢妥仑（一种新型口服头孢菌素）、两种新型恶唑烷酮（U-100592和U-100766）以及其他口服和胃肠外用药对203株青霉素敏感和耐药肺炎球菌的活性。
Activities of RPR 106972 (a new oral streptogramin), cefditoren (a new oral cephalosporin), two new oxazolidinones (U-100592 and U-100766), and other oral and parenteral agents against 203 penicillin-susceptible and -resistant pneumococci.
作者信息
Spangler S K, Jacobs M R, Appelbaum P C
机构信息
Department of Pathology (Clinical Microbiology), Hershey Medical Center, Pennsylvania 17033, USA.
出版信息
Antimicrob Agents Chemother. 1996 Feb;40(2):481-4. doi: 10.1128/AAC.40.2.481.
Abstract
Agar dilution was used to determine the MICs of RPR 106972 (a new oral streptogramin), cefditoren (a new oral cephalosporin), two new oxazolidinones (U-100592 and U-100766), and other oral and parenteral agents for 203 penicillin-susceptible and -resistant pneumococci. All pneumococci were inhibited by RPR 106972 at < or = 0.5 microgram/ml. Cefditoren was very active against all pneumococcal groups, with MICs of < or = 2.0 micrograms/ml. Amoxicillin with or without clavulanate was the next most active oral beta-lactam, followed by cefdinir, cefuroxime, cefpodoxime, and cefprozil. U-100592 and U-100766 were very active against all classes of pneumococci, with all MICs < or = 1.0 microgram/ml.
摘要
采用琼脂稀释法测定了RPR 106972（一种新型口服链阳菌素）、头孢妥仑（一种新型口服头孢菌素）、两种新型恶唑烷酮（U - 100592和U - 100766）以及其他口服和胃肠外用药对203株青霉素敏感和耐药肺炎球菌的最低抑菌浓度（MIC）。所有肺炎球菌对RPR 106972的MIC均≤0.5微克/毫升。头孢妥仑对所有肺炎球菌群均具有很高活性，MIC≤2.0微克/毫升。含或不含克拉维酸的阿莫西林是活性次之的口服β-内酰胺类药物，其次是头孢地尼、头孢呋辛、头孢泊肟和头孢丙烯。U - 100592和U - 100766对所有类型的肺炎球菌均具有很高活性，所有MIC均≤1.0微克/毫升。
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