接受诺氟沙星预防治疗的癌症患者粪便菌群中耐氟喹诺酮大肠杆菌的出现。
Emergence of fluoroquinolone-resistant Escherichia coli in fecal flora of cancer patients receiving norfloxacin prophylaxis.
作者信息
Carratala J, Fernandez-Sevilla A, Tubau F, Dominguez M A, Gudiol F
机构信息
Services of Infectious Diseases, University of Barcelona, Spain.
出版信息
Antimicrob Agents Chemother. 1996 Feb;40(2):503-5. doi: 10.1128/AAC.40.2.503.
Abstract
We studied 122 stool samples collected from 25 patients with hematologic malignancies who received prophylactic norfloxacin. Fecal samples were obtained at admission and twice weekly thereafter during prophylaxis. Fluoroquinolone-resistant Escherichia coli strains were isolated from the feces of 10 (40%) of the patients; two patients had fluoroquinolone-resistant E. coli strains prior to beginning norfloxacin treatment, and in the other eight patients, the strains appeared subsequently. One patient developed fluoroquinolone-resistant E. coli bacteremia after 10 days of norfloxacin administration.
摘要
我们研究了从25例接受预防性诺氟沙星治疗的血液系统恶性肿瘤患者中收集的122份粪便样本。在入院时以及预防治疗期间每周两次采集粪便样本。从10例（40%）患者的粪便中分离出耐氟喹诺酮的大肠杆菌菌株；2例患者在开始诺氟沙星治疗前就有耐氟喹诺酮的大肠杆菌菌株，另外8例患者的菌株随后出现。1例患者在使用诺氟沙星10天后发生了耐氟喹诺酮的大肠杆菌菌血症。
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