编码CTX-M-1（MEN-1）和CTX-M-2的β-内酰胺酶基因序列及其氨基酸序列与其他β-内酰胺酶氨基酸序列的关系。
Sequences of beta-lactamase genes encoding CTX-M-1 (MEN-1) and CTX-M-2 and relationship of their amino acid sequences with those of other beta-lactamases.
作者信息
Bauernfeind A, Stemplinger I, Jungwirth R, Ernst S, Casellas J M
机构信息
Max von Pettenkofer-Institut, Munich, Federal Republic of Germany.
出版信息
Antimicrob Agents Chemother. 1996 Feb;40(2):509-13. doi: 10.1128/AAC.40.2.509.
Abstract
Amino acid sequences determined either by protein sequencing or by DNA sequencing are identical for cefotaximases CTX-M-1 and MEN-1, whereas CTX-M-2 is 84% identical to CTX-M-1/MEN-1. Both beta-lactamases are distantly related to other plasmidic class A enzymes (homology to TEM-1 is 38.1% for CTX-M-1/MEN-1 and 36.5% for CTX-M-2); the closest relationship was with the chromosomal beta-lactamase of Klebsiella oxytoca E23004 (homologies of 74.5% for CTX-M-1/MEN-1 and 77.9% for CTX-M-2). The cefotaximases CTX-M-1/MEN-1 and CTX-M-2 represent two members of a new subgroup of plasmidic class A beta-lactamases.
摘要
通过蛋白质测序或DNA测序确定的头孢他啶酶CTX-M-1和MEN-1的氨基酸序列是相同的，而CTX-M-2与CTX-M-1/MEN-1的序列一致性为84%。这两种β-内酰胺酶与其他质粒A类酶的亲缘关系较远（CTX-M-1/MEN-1与TEM-1的同源性为38.1%，CTX-M-2与TEM-1的同源性为36.5%）；它们与产酸克雷伯菌E23004的染色体β-内酰胺酶关系最为密切（CTX-M-1/MEN-1与该酶的同源性为74.5%，CTX-M-2与该酶的同源性为77.9%）。头孢他啶酶CTX-M-1/MEN-1和CTX-M-2代表了质粒A类β-内酰胺酶一个新亚组的两个成员。
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本文引用的文献
1
Genetics of extended-spectrum beta-lactamases.超广谱β-内酰胺酶的遗传学
Eur J Clin Microbiol Infect Dis. 1994;13 Suppl 1:S2-11. doi: 10.1007/BF02390679.
2
The structure of beta-lactamases.β-内酰胺酶的结构
Philos Trans R Soc Lond B Biol Sci. 1980 May 16;289(1036):321-31. doi: 10.1098/rstb.1980.0049.
3
The neighbor-joining method: a new method for reconstructing phylogenetic trees.邻接法：一种重建系统发育树的新方法。
Mol Biol Evol. 1987 Jul;4(4):406-25. doi: 10.1093/oxfordjournals.molbev.a040454.
4
Fast and sensitive multiple sequence alignments on a microcomputer.在微型计算机上进行快速且灵敏的多序列比对。
Comput Appl Biosci. 1989 Apr;5(2):151-3. doi: 10.1093/bioinformatics/5.2.151.
5
Chromosomal beta-lactamase of Klebsiella oxytoca, a new class A enzyme that hydrolyzes broad-spectrum beta-lactam antibiotics.产酸克雷伯菌的染色体β-内酰胺酶，一种可水解广谱β-内酰胺抗生素的新型A类酶。
Antimicrob Agents Chemother. 1989 Jan;33(1):63-70. doi: 10.1128/AAC.33.1.63.
6
A new plasmidic cefotaximase in a clinical isolate of Escherichia coli.
Infection. 1990 Sep-Oct;18(5):294-8. doi: 10.1007/BF01647010.
7
Cefotaxime-hydrolysing activity of the beta-lactamase of Klebsiella oxytoca D488 could be related to a threonine residue at position 140.产酸克雷伯菌D488的β-内酰胺酶的头孢噻肟水解活性可能与140位的苏氨酸残基有关。
FEMS Microbiol Lett. 1991 Jun 15;65(2):185-92. doi: 10.1016/0378-1097(91)90301-p.
8
Comparison of the sequences of class A beta-lactamases and of the secondary structure elements of penicillin-recognizing proteins.A类β-内酰胺酶序列与青霉素识别蛋白二级结构元件的比较。
Antimicrob Agents Chemother. 1991 Nov;35(11):2294-301. doi: 10.1128/AAC.35.11.2294.
9
Cloning and nucleotide sequencing of the gene encoding the beta-lactamase from Citrobacter diversus.
FEMS Microbiol Lett. 1991 Sep 15;67(1):79-84. doi: 10.1016/0378-1097(91)90448-j.
10
A new plasmidic cefotaximase from patients infected with Salmonella typhimurium.从感染鼠伤寒沙门氏菌的患者中分离出一种新型质粒头孢菌素酶。
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