Ayres J G
Chest Research Institute, Birmingham Heartlands Hospital, UK.
Monaldi Arch Chest Dis. 1995 Dec;50(6):469-71.
Gastro-oesophageal reflux (GOR) and asthma are both common but there are causal associations between the two. Although frank microaspiration into the trachea has been documented, in most patients vagal reflex pathways from lower oesophageal receptors are the predominant cause of airway narrowing or cough. Equally, the smooth muscle relaxing drugs used for the treatment of asthma can cause reflux to occur as can hyperinflation associated with more significant asthma. Controlling the symptoms of GOR with H2 blockers or proton pump inhibitors does not necessarily improve asthma control, while the place for surgery as an attempt to reduce asthma symptoms is open to debate.
胃食管反流（GOR）和哮喘都很常见，且二者之间存在因果关联。尽管已记录到有明显的微量误吸进入气管的情况，但在大多数患者中，来自食管下段感受器的迷走神经反射通路是气道狭窄或咳嗽的主要原因。同样，用于治疗哮喘的平滑肌松弛药物可导致反流，与更严重哮喘相关的肺过度充气也会导致反流。使用H2受体阻滞剂或质子泵抑制剂控制胃食管反流症状并不一定会改善哮喘控制情况，而手术作为减轻哮喘症状的一种尝试，其作用仍存在争议。
