Bakkaloglu A, Saatci U, Soylemezoglu O, Ozen S, Topaloglu R, Besbas N, Saatci I
Pediatric Nephrology Department, Hacettepe University Children's Hospital, Ankara, Turkey.
J Chemother. 1996 Feb;8(1):59-62. doi: 10.1179/joc.1996.8.1.59.
It is very important to treat patients with upper urinary tract infections (UTIs) promptly and effectively because of the potential sequelae. In the present study we compare the efficacy of the two cephalosporins, ceftriaxone and cefotaxime, in childhood pyelonephritis. The study protocal included 10 days of drug therapy. Both in patients receiving ceftriaxone and cefotaxime, successful eradication was achieved at the second day of therapy. The overall cure rate was significantly better in the ceftriaxone group than the cefotaxime group in terms of recurrence and reinfections (p < 0.05). Furthermore, in the complicated group, ceftriaxone was slightly superior to cefotaxime, approaching significance in terms of preventing recurrent infections. No serious adverse effects were observed in either of the groups. The present study has shown that ceftriaxone exhibits favorable clinical and bacteriologic efficacy in patients with complicated and uncomplicated upper UTI. Once-daily injection of ceftriaxone in children is also an attractive advantage of the drug when compared to twice-daily cefotaxime.
由于存在潜在的后遗症，及时有效地治疗上尿路感染（UTI）患者非常重要。在本研究中，我们比较了两种头孢菌素（头孢曲松和头孢噻肟）在儿童肾盂肾炎中的疗效。研究方案包括10天的药物治疗。在接受头孢曲松和头孢噻肟治疗的患者中，治疗第二天均实现了成功根除。在复发和再感染方面，头孢曲松组的总体治愈率显著优于头孢噻肟组（p < 0.05）。此外，在复杂组中，头孢曲松略优于头孢噻肟，在预防复发性感染方面接近显著差异。两组均未观察到严重不良反应。本研究表明，头孢曲松在复杂性和非复杂性上尿路感染患者中表现出良好的临床和细菌学疗效。与每日两次注射头孢噻肟相比，儿童每日一次注射头孢曲松也是该药的一个吸引人的优势。
