Cheville J C, Bromley C, Argenyi Z B
Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City 52242, USA.
J Cutan Pathol. 1995 Dec;22(6):546-50. doi: 10.1111/j.1600-0560.1995.tb01149.x.
Keratoacanthoma (KA) is generally considered to be a clinically and histologically distinct entity, but it often remains difficult to separate from well-differentiated squamous cell carcinoma (WDSCC). Recently, trisomy 7 has been identified in squamous cell carcinoma of the skin. In this study, we examined classical KA (n = 6), WDSCC (n = 7) and squamous cell carcinoma with KA-like features (SCC-KA) (n = 8) for trisomy 7 by fluorescence in-situ hybridization (FISH) to determine if this chromosomal abnormality is unique to squamous lesions diagnosed as WDSCC, or shared by both KA and SCC. In addition, the pertinent clinical-histopathologic findings were summarized. Trisomy 7 was identified in one KA, one SCC-KA and two WDSCC. This study demonstrates that there is a chromosomal abnormality shared by KA and SCC, providing further evidence that KA is most likely a form of SCC. Further studies are required to determine if trisomy 7 in these lesions is of prognostic significance.
角化棘皮瘤（KA）通常被认为是一种在临床和组织学上都有明显特征的实体，但它常常难以与高分化鳞状细胞癌（WDSCC）区分开来。最近，在皮肤鳞状细胞癌中发现了7号染色体三体。在本研究中，我们通过荧光原位杂交（FISH）检测了经典型KA（n = 6）、WDSCC（n = 7）和具有KA样特征的鳞状细胞癌（SCC-KA）（n = 8）中的7号染色体三体，以确定这种染色体异常是否仅存在于诊断为WDSCC的鳞状病变中，还是KA和SCC都有。此外，还总结了相关的临床组织病理学发现。在1例KA、1例SCC-KA和2例WDSCC中发现了7号染色体三体。本研究表明，KA和SCC存在共同的染色体异常，进一步证明KA很可能是SCC的一种形式。需要进一步研究来确定这些病变中的7号染色体三体是否具有预后意义。
