Bono G, Mauri M, Sinforiani E, Barbarini G, Minoli L, Fea M
IRCCS C. Mondino, University of Pavia, Italy.
Addiction. 1996 Feb;91(2):263-8. doi: 10.1046/j.1360-0443.1996.9122638.x.
The present study aimed to describe the cognitive status of a group of HIV-positive asymptomatic intravenous drug users (IVDU) and changes which occurred over a 12-month follow-up period. Forty-two HIV positive IVDU were selected and matched for age, sex, educational level and pattern of drug abuse with 39 seronegative IVDU controls. Baseline and follow-up evaluation included neuropsychological tests exploring attention, language, memory, logic and visuomotor abilities, biological markers and clinical parameters. About one-third of both seropositive and seronegative subjects showed at baseline slight cognitive deficits, which did not change during the follow-up period.
本研究旨在描述一组艾滋病毒呈阳性的无症状静脉注射吸毒者的认知状况，以及在为期12个月的随访期内发生的变化。选取了42名艾滋病毒呈阳性的静脉注射吸毒者，并在年龄、性别、教育水平和药物滥用模式方面与39名血清阴性的静脉注射吸毒者对照组进行匹配。基线和随访评估包括探索注意力、语言、记忆、逻辑和视觉运动能力的神经心理学测试、生物标志物和临床参数。血清阳性和血清阴性受试者中约三分之一在基线时表现出轻微的认知缺陷，这些缺陷在随访期间没有变化。
