人抗β2糖蛋白I IgG自身抗体与抗心磷脂抗体之间的分析和临床关系。
Analytical and clinical relationships between human IgG autoantibodies to beta 2 glycoprotein I and anticardiolipin antibodies.
作者信息
El-Kadi H S, Keil L B, DeBari V A
机构信息
Department of Medicine, Seton Hall University School of Graduate Medical Education, Paterson, New Jersey, USA.
出版信息
J Rheumatol. 1995 Dec;22(12):2233-7.
OBJECTIVE
To examine IgG anti-beta 2 glycoprotein I (anti-beta 2 GPI) binding in 82 sera referred for anticardiolipin antibody (aCL) testing and to develop preliminary clinical correlations with antiphospholipid syndrome (APS).
METHODS
Immunoassay of IgG cofactor dependent aCL and IgG anti-beta 2 GPI antibodies and retrospective chart review.
RESULTS
Forty-four sera exhibited normal (< or = 22 GPL units) aCL activity, 18 had moderate binding activity (23-45 GPL units), and 20 had high (> or = 46 GPL units) binding activity to cardiolipin. Among these groups, 6 of the 20 sera in the high GPL group had elevated anti-beta 2 GPI. This correlated strongly with 2 or more clinical manifestations of APS.
CONCLUSION
Anti-beta 2 GPI activity may be a more valuable indicator of APS than aCL.
目的
检测82份送检抗心磷脂抗体（aCL）的血清中IgG抗β2糖蛋白I（抗β2GPI）的结合情况，并与抗磷脂综合征（APS）建立初步临床关联。
方法
对IgG辅助因子依赖性aCL和IgG抗β2GPI抗体进行免疫测定，并回顾性查阅病历。
结果
44份血清显示aCL活性正常（≤22 GPL单位），18份具有中度结合活性（23 - 45 GPL单位），20份对心磷脂具有高结合活性（≥46 GPL单位）。在这些组中，高GPL组的20份血清中有6份抗β2GPI升高。这与APS的2种或更多种临床表现密切相关。
结论
抗β2GPI活性可能是比aCL更有价值的APS指标。
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