哌拉他汀A，一种由放线菌产生的新型选择性丝氨酸羧肽酶抑制剂。II. 物理化学性质及结构测定。

Piperastatin A, a new selective serine carboxypeptidase inhibitor produced by actinomycete. II. Physico-chemical properties and structure determination.

作者信息

Murakami S, Takahashi Y, Naganawa H, Takeuchi T, Aoyagi T

机构信息

Institute of Microbial Chemistry, Tokyo, Japan.

出版信息

J Enzyme Inhib. 1996;10(2):105-14. doi: 10.3109/14756369609020163.

DOI:10.3109/14756369609020163

Abstract

Piperastatin A, a new inhibitor of serine carboxypeptidase, was discovered in the culture broth of Streptomyces lavendofoliae MJ908-WF13. The molecular formula of piperastatin A was established as C38H67N9C10 by HRFAB-MS and elemental analysis. The structure was determined to be N-formyl-allo Ile-Thr-Leu-Val-Pip-Leu-Pip (Pip = hexahydropyridadine-3-carboxylic acid) by various spectral analyses of piperastatin A and piperastatin A methylester.

摘要

哌拉他汀A是一种新型丝氨酸羧肽酶抑制剂，从薰衣草链霉菌MJ908-WF13的培养液中分离得到。通过高分辨快原子轰击质谱（HRFAB-MS）和元素分析确定哌拉他汀A的分子式为C38H67N9C10。通过对哌拉他汀A及其甲酯进行多种光谱分析，确定其结构为N-甲酰基-别异亮氨酸-苏氨酸-亮氨酸-缬氨酸-哌啶酸-亮氨酸-哌啶酸（哌啶酸=六氢吡啶-3-羧酸）。

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