Buzsáki G, Grastyán E, Tveritskaya I N, Czopf J
Electroencephalogr Clin Neurophysiol. 1979 Jul;47(1):64-74. doi: 10.1016/0013-4694(79)90033-6.
Hippocampal evoked potentials (EPs) and EEG responses were studied in rats, using a classical conditioning paradigm (water, US), with a spatially discontiguous CS-US arrangement in order to separate the CS and goal-related responses. In early training, when the orienting score was high, the tone CS, instead of eliciting a definite EP, usually reset hippocampal theta activity in phase, i.e. theta rhythm became time-locked to CS. With further training, orienting activity (ORI) decreased to the preconditioning level, and this was associated with the recurrence of short-latency and high voltage hippocampal EPs, similar to those observed during habituation. This high voltage EP predicted that the animal would not orient any more towards CS. This correlation was confirmed by behavioural (satiation, shock US) and by pharmacological (scopolamine HBr, 2 mg/kg) treatments, all of which reduced the ORI score. Hippocampal EEGs also showed characteristic changes during conditioning. ORI towards CS was accompanied by higher frequency spectral peaks (9 c/sec) than response to US (7--8 c/sec). This correlation was seen both across sessions and within trials. We conclude that the above changes are related to orienting, attentional factors rather than to movement-related variables.
利用经典条件反射范式（水，非条件刺激），采用空间上不连续的条件刺激-非条件刺激安排，以分离条件刺激和目标相关反应，研究了大鼠海马诱发电位（EPs）和脑电图反应。在早期训练中，当定向分数较高时，音调条件刺激通常不会引发明确的诱发电位，而是使海马θ活动同相重置，即θ节律与条件刺激时间锁定。随着进一步训练，定向活动（ORI）降至预处理水平以下，这与短潜伏期和高电压海马诱发电位的再次出现有关，类似于习惯化期间观察到的情况。这种高电压诱发电位预示动物不再对条件刺激进行定向。行为学（饱足、电击非条件刺激）和药理学（氢溴酸东莨菪碱，2mg/kg）处理均证实了这种相关性，所有这些处理均降低了定向分数。脑电图在条件反射过程中也表现出特征性变化。对条件刺激的定向伴随着比非条件刺激反应更高的频谱峰值（9赫兹）。这种相关性在各次训练期间和单次试验中均可见。我们得出结论，上述变化与定向、注意力因素有关，而非与运动相关变量有关。
