克罗地亚北部和南部人群基于七个聚合酶链反应（PCR）位点的数据。

Northern and southern Croatian population data on seven PCR-based loci.

作者信息

Keys K M, Budowle B, Andelinovic S, Definis-Gojanovic M, Drmic I, Mladen M, Primorac D

机构信息

Forensic Science Research and Training Center, FBI Academy, Quantico, Virginia 22135, USA.

出版信息

Forensic Sci Int. 1996 Aug 15;81(2-3):191-9. doi: 10.1016/s0379-0738(96)01950-0.

DOI:10.1016/s0379-0738(96)01950-0

PMID:8837495

Abstract

Northern and southern Croatian sample populations were typed at seven PCR-based loci -LDLR, GYPA, HBGG, D7S8, Gc, HLA-DQA1 and D1S80. The results show that all loci meet Hardy-Weinberg expectations and that there is little evidence for association of alleles between loci. Allelic frequency distributions at all loci, except HLA-DQA1, show no differences between the northern and southern Croatian sample populations. Moreover, the population data for Croatians are similar to U.S. Caucasians; only HLA-DQA1 for southern Croatians was statistically different compared with U.S. Caucasians. A Croatian population database(s) has been created and can be used for forensic analyses to estimate the frequency of a multiple locus DNA profile.

摘要

对克罗地亚北部和南部的样本群体在7个基于聚合酶链反应（PCR）的基因座进行了分型，这些基因座分别是低密度脂蛋白受体（LDLR）、血型糖蛋白A（GYPA）、β-珠蛋白（HBGG）、D7S8、维生素转运蛋白（Gc）、人类白细胞抗原-DQA1（HLA-DQA1）和D1S80。结果显示，所有基因座均符合哈迪-温伯格平衡预期，且几乎没有证据表明基因座之间的等位基因存在关联。除HLA-DQA1外，所有基因座的等位基因频率分布在克罗地亚北部和南部样本群体之间均无差异。此外，克罗地亚人的群体数据与美国白种人相似；只有克罗地亚南部人群的HLA-DQA1与美国白种人相比存在统计学差异。现已建立了克罗地亚人群数据库，可用于法医分析，以估计多位点DNA图谱的频率。