Bloom J D, Hamor R E, Gerding P A
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana 61801, USA.
J Am Vet Med Assoc. 1996 Oct 1;209(7):1271-4.
To evaluate clinical signs of ocular blastomycosis in dogs, to determine response of blastomycosis-infected eyes to treatment with systemically administered amphotericin B and ketoconazole, and to identify prognostic indicators of successful antifungal treatment.
Retrospective study.
73 dogs.
Medical records were reviewed for all dogs with confirmed blastomycosis and ocular disease seen at our hospital between 1985 and 1993.
6 eyes had anterior segment disease, 24 had posterior segment disease, and 78 had endophthalmitis. 40 eyes were treated with a combination of amphotericin B and ketoconazole, and 16 of the 40 responded favorably. However, 16 of the 24 eyes that were not severely affected responded favorably, but none of the 16 eyes that were severely affected did.
Dogs with blastomycosis had posterior segment disease, without complete retinal separation, had a good prognosis for retaining vision. Results of histologic examination suggested that secondary glaucoma was a manifestation of endophthalmitis and was indicative of a grave prognosis for response to antifungal and antiglaucoma treatment.
评估犬眼部芽生菌病的临床症状，确定芽生菌病感染的眼睛对全身应用两性霉素B和酮康唑治疗的反应，并确定抗真菌治疗成功的预后指标。
回顾性研究。
73只犬。
回顾了1985年至1993年间在我院确诊患有芽生菌病和眼部疾病的所有犬的病历。
6只眼患有前段疾病，24只眼患有后段疾病，78只眼患有眼内炎。40只眼接受了两性霉素B和酮康唑联合治疗，其中16只反应良好。然而，24只未受严重影响的眼中有16只反应良好，但16只受严重影响的眼中无一反应良好。
患有芽生菌病的犬若有后段疾病且视网膜未完全脱离，则保留视力的预后良好。组织学检查结果表明，继发性青光眼是眼内炎的一种表现，提示抗真菌和抗青光眼治疗反应的预后不良。
