Langlois Daniel K, Pelosi Augusta, Kruger John M
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
J Am Anim Hosp Assoc. 2013 Jul-Aug;49(4):273-80. doi: 10.5326/JAAHA-MS-5874. Epub 2013 May 20.
A 4 yr old spayed female Labrador retriever with clinical signs of blindness, cutaneous lesions, coughing, inappetence, and lethargy was diagnosed with disseminated blastomycosis based on cytologic (skin and lymph node aspirates) and histopathologic (skin biopsy) examinations of tissue samples. The dog deteriorated clinically during hospitalization and developed sustained ventricular tachycardia. Echocardiography revealed pericardial effusion, a nodule associated with the left ventricular papillary muscle, and a right atrial mural lesion. Therapy for myocardial performance and glaucoma was initiated. A combination of itraconazole and fluconazole successfully treated the dog. The dog regained vision in the left eye (oculus sinister [OS]) and had no residual cardiac disease detectable by either electrocardiography or echocardiography. This report is unique in documenting survival from intracardiac blastomycosis and in the use of combination azole therapy for treating disseminated disease with intraocular involvement.
一只4岁已绝育的雌性拉布拉多寻回犬出现失明、皮肤病变、咳嗽、食欲不振和嗜睡等临床症状，基于组织样本的细胞学检查（皮肤和淋巴结穿刺物）和组织病理学检查（皮肤活检），被诊断为播散性芽生菌病。这只狗在住院期间病情恶化，出现了持续性室性心动过速。超声心动图显示有心包积液、与左心室乳头肌相关的一个结节以及右心房壁病变。开始了针对心肌功能和青光眼的治疗。伊曲康唑和氟康唑联合用药成功治愈了这只狗。这只狗左眼恢复了视力，并且通过心电图或超声心动图均未检测到残留的心脏疾病。本报告的独特之处在于记录了心脏芽生菌病的存活情况以及使用唑类联合疗法治疗伴有眼部受累的播散性疾病。
