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玻璃纤维与肺癌的流行病学

Epidemiology of fibrous glass and lung cancer.

作者信息

Weiss W

出版信息

Am J Ind Med. 1996 Jul;30(1):105-8. doi: 10.1002/(SICI)1097-0274(199607)30:1<105::AID-AJIM18>3.0.CO;2-1.

DOI:10.1002/(SICI)1097-0274(199607)30:1<105::AID-AJIM18>3.0.CO;2-1
PMID:8837692
Abstract

In a recent commentary, Infante et al. [1994] summarized some of the epidemiologic literature on the relationship between glass wool and lung cancer. They concluded that this material is carcinogenic for the lung in humans. A review of the commentary in comparison with the original papers covered reveals that their analysis was incomplete and characterized by selection bias. A more careful examination of the literature cited and other relevant publications shows that the data cited by Infante et al. are subject to the errors of chance and confounding and that the association when present is inconsistent, weak, and lacks a dose-response relationship. Therefore, a conclusion of causality cannot be justified.

摘要

在最近的一篇评论中,因凡特等人[1994年]总结了一些关于玻璃棉与肺癌关系的流行病学文献。他们得出结论,这种材料对人类肺部具有致癌性。将该评论与所涵盖的原始论文进行比较后发现,他们的分析并不完整,且存在选择偏倚。对所引用的文献及其他相关出版物进行更仔细的研究表明,因凡特等人引用的数据存在随机误差和混杂因素,而且即使存在关联,也是不一致、微弱的,并且缺乏剂量反应关系。因此,得出因果关系的结论是不合理的。

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