Bartram H P, Gostner A, Kelber E, Dusel G, Weimer A, Scheppach W, Kasper H
Department of Medicine, University of Wuerzburg, Germany.
Nutr Cancer. 1996;25(1):71-8. doi: 10.1080/01635589609514429.
Diet-induced changes in fecal excretion of secondary bile acids, certain neutral sterols, and bacterial enzyme activities are known to play a role in colon cancer development. Dietary fish oil (FO) has been implicated as a protective agent in colon carcinogenesis. In the present study, the effects of FO and corn oil (CO) on these fecal parameters were investigated in 24 healthy volunteers consuming a low- or a high-fat diet (30% or 50% of energy derived from fat). After four weeks of FO or CO supplementation (4.4 g of n-3 fatty acids/day), no significant differences were noted for fecal activities of beta-glucuronidase, beta-glucosidase, and sulfatase, nor was fecal bile acid excretion significantly affected by FO or CO consumption. However, daily excretion of the putative colon carcinogen 4-cholesten-3-one was significantly lower in the FO than in the CO period during low- and high-fat experiments. This may be another biochemical mechanism by which FO exerts its protective effect on colon cancer development.
饮食引起的次级胆汁酸、某些中性固醇的粪便排泄变化以及细菌酶活性在结肠癌发展中发挥作用，这是已知的。膳食鱼油（FO）被认为是结肠癌发生过程中的一种保护剂。在本研究中，对24名食用低脂或高脂饮食（分别为30%或50%的能量来自脂肪）的健康志愿者，研究了鱼油（FO）和玉米油（CO）对这些粪便参数的影响。在补充FO或CO四周（每天4.4克n-3脂肪酸）后，β-葡萄糖醛酸酶、β-葡萄糖苷酶和硫酸酯酶的粪便活性未观察到显著差异，食用FO或CO对粪便胆汁酸排泄也没有显著影响。然而，在低脂和高脂实验期间，FO阶段推定的结肠癌致癌物4-胆甾烯-3-酮的每日排泄量显著低于CO阶段。这可能是FO对结肠癌发展发挥保护作用的另一种生化机制。
