Bartram H P, Gostner A, Kelber E, Dusel G, Scheppach W, Kasper H
Department of Medicine, University of Würzburg.
Z Ernahrungswiss. 1998;37 Suppl 1:139-41.
Diet-induced increases in fecal excretion of secondary bile acids (deoxy- and lithocholic acid) and certain neutral sterols (4-cholesten-3-one and 5a-cholestan-3-one) play a role in colon cancer development, whereas dietary fish oil (FO) has been implicated as a protective agent. In the present study the effects of FO and corn oil (CO) on these fecal parameters were investigated in 12 healthy volunteers consuming a low fat (30% of energy) controlled basal diet. After 4 weeks of FO supplementation (4.4 g omega-3 fatty acids/day), daily excretion of lithocholic acid showed a trend to lower values compared to CO consumption (p = 0.2), whereas other bile acids were not different during both study periods. Daily excretion of the putative colon carcinogen 4-cholesten-3-one was significantly lower in the FO compared to the CO period. This may be another biochemical mechanism by which FO exerts its protective effect on colon cancer development.
饮食诱导的次级胆汁酸（脱氧胆酸和石胆酸）以及某些中性固醇（4-胆甾烯-3-酮和5α-胆甾烷-3-酮）粪便排泄增加在结肠癌发展中起作用，而膳食鱼油（FO）被认为是一种保护剂。在本研究中，在12名食用低脂（占能量的30%）对照基础饮食的健康志愿者中研究了FO和玉米油（CO）对这些粪便参数的影响。在补充FO（4.4克ω-3脂肪酸/天）4周后，与食用CO相比，石胆酸的每日排泄量有降低的趋势（p = 0.2），而在两个研究期间其他胆汁酸没有差异。与CO期相比，FO期推定的结肠癌致癌物4-胆甾烯-3-酮的每日排泄量显著降低。这可能是FO对结肠癌发展发挥保护作用的另一种生化机制。
