Axemo P, Brauner A, Pettersson M, Eriksson L, Rwamushaija E, Bergström S
Department of Obstetrics and Gynaecology, University Hospital, Uppsala, Sweden.
Gynecol Obstet Invest. 1996;41(2):113-7. doi: 10.1159/000292054.
The aim of the study was to investigate inflammatory cytokines, interleukin-1 beta (IL-1 beta), interleukin-1 receptor antagonist (IL-1ra), IL-6, IL-8 in amniotic fluid, in a cohort of Swedish pregnant women from early to late pregnancy and Mozambican late pregnant women with and without signs of histologic chorioamnionitis. Eleven Swedish women were studied from early pregnancy (week 16-17) to late pregnancy (week 37-38). Amniotic fluid was collected via amniocentesis in early pregnancy and also in late pregnancy during elective Caesarean section. From Mozambican women, amniotic fluid was harvested transmurally through the uterus wall during elective Caesarean section. Half of the group of 30 women showed histological signs of chorioamnionitis and half of the group did not show such signs. A statistical, significant increase in IL-1ra, Il-6 and IL-8 values from early to late pregnancy was seen in the Swedish pregnant women. Among the Mozambican women, no statistically significant increase in the above-mentioned interleukins was observed when comparing women with and without histological signs of chorioamnionitis. Term Swedish and Mozambican women did not show differences in cytokine levels. There were no detectable values of IL-1 beta in either Swedish or Mozambican women. IL-1ra, IL-6 and IL-8 increased in amniotic fluid from the second to the third trimester in the Swedish cohort. No correlation was found between histological chorioamnionitis and elevated cytokine levels of amniotic fluid in term pregnant women not in labour. An equally good cytokine response was found among Swedish and Mozambican third-trimester non-labouring women.
该研究的目的是调查瑞典孕妇从妊娠早期到晚期以及莫桑比克晚期孕妇（有无组织学绒毛膜羊膜炎体征）羊水内的炎性细胞因子，即白细胞介素-1β（IL-1β）、白细胞介素-1受体拮抗剂（IL-1ra）、IL-6、IL-8。对11名瑞典女性从妊娠早期（第16 - 17周）至妊娠晚期（第37 - 38周）进行了研究。在妊娠早期通过羊膜腔穿刺术收集羊水，在妊娠晚期选择性剖宫产时也收集羊水。对于莫桑比克女性，在选择性剖宫产时经子宫壁穿刺采集羊水。30名女性中有一半显示出绒毛膜羊膜炎的组织学体征，另一半则未显示此类体征。瑞典孕妇从妊娠早期到晚期，IL-1ra、IL-6和IL-8值有统计学意义的显著升高。在莫桑比克女性中，比较有和没有绒毛膜羊膜炎组织学体征的女性时，上述白细胞介素没有观察到统计学意义的升高。足月的瑞典和莫桑比克女性细胞因子水平没有差异。瑞典和莫桑比克女性中均未检测到IL-1β值。瑞典队列中羊水内IL-1ra、IL-6和IL-8从妊娠中期到晚期升高。在未临产的足月孕妇中，未发现组织学绒毛膜羊膜炎与羊水细胞因子水平升高之间存在相关性。在瑞典和莫桑比克妊娠晚期未临产的女性中发现了同样良好的细胞因子反应。
