艾滋病中的炎症以及巨噬细胞在脑病理学中的作用。
Inflammation in AIDS and the role of the macrophage in brain pathology.
作者信息
Achim C L, Wiley C A
机构信息
University of Pittsburgh School of Medicine, Division of Neuropathology, Pennsylvania 15213, USA.
出版信息
Curr Opin Neurol. 1996 Jun;9(3):221-5. doi: 10.1097/00019052-199606000-00013.
Abstract
HIV-associated dementia complex is the most severe neurologic complication of AIDS. The pathologic substrate of the complex, termed HIV encephalitis, is marked by abundant infection and activation of brain macrophages. The pathogenesis of neurologic damage in HIV encephalitis is essentially undefined. Most current investigations are focused on potential viral or macrophage neurotoxins.
摘要
人类免疫缺陷病毒相关性痴呆综合征是艾滋病最严重的神经并发症。该综合征的病理基础，即所谓的人类免疫缺陷病毒脑炎，其特征是脑巨噬细胞大量感染和激活。人类免疫缺陷病毒脑炎中神经损伤的发病机制基本尚不明确。目前大多数研究集中在潜在的病毒或巨噬细胞神经毒素上。
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