Brinkmann B, Sajantila A, Goedde H W, Matsumoto H, Nishi K, Wiegand P
Institute of Legal Medicine, Westfälische Wilhelms-Universität Münster, Germany.
Eur J Hum Genet. 1996;4(3):175-82. doi: 10.1159/000472192.
Eight different population samples (Moroccans, Ovambos, Papuans, Australian aborigines, Germans, Turks, Japanese and Chinese) were studied using the tetranucleotide short tandem repeat systems HumTHO1 (THO1), Hum VWFA31 (VWA) and HumACTBP2 (ACTBP2). Ten alleles were differentiated in THO1, 11 alleles in VWA and 28 alleles in ACTBP2. THO1 showed 1 bp deletions in the repeat region, VWA sequence and structure variations of the 4-bp repeat motif and ACTBP2 sequence, structure and length variations in the repeat array and deletions/insertions (1-6 bp) in the flanking regions. A phylogenetic tree was constructed (UPGMA method) leading to branches which grouped Germans and Turks, Japanese and Chinese, and Papuans and Australian aborigines.
使用四核苷酸短串联重复序列系统HumTHO1（THO1）、Hum VWFA31（VWA）和HumACTBP2（ACTBP2）对八个不同的人群样本（摩洛哥人、奥万博人、巴布亚人、澳大利亚原住民、德国人、土耳其人、日本人及中国人）进行了研究。在THO1中鉴别出10个等位基因，在VWA中鉴别出11个等位基因，在ACTBP2中鉴别出28个等位基因。THO1在重复区域出现1 bp缺失，VWA在4-bp重复基序存在序列和结构变异，ACTBP2在重复阵列存在序列、结构和长度变异，侧翼区域存在1-6 bp的缺失/插入。构建了一个系统发育树（UPGMA法），结果显示德国人及土耳其人、日本人和中国人、巴布亚人和澳大利亚原住民分别聚为一支。
