卵巢、乳腺和结肠腺癌患者的黏蛋白样癌相关抗原血清水平

Mucin-like carcinoma-associated antigen serum levels in patients with adenocarcinomas originating from ovary, breast and colon.

作者信息

Bon G G, Verheijen R H, Zuetenhorst J M, van Kamp G J, Verstraeten A A, Kenemans P

机构信息

Department of Obstetrics and Gynecology, Free University Hospital, Amsterdam, The Netherlands.

出版信息

Gynecol Obstet Invest. 1996;42(1):58-62. doi: 10.1159/000291890.

DOI:10.1159/000291890

PMID:8840180

Abstract

The mucin-like carcinoma-associated antigen (MCA) enzyme immunoassay was tested in 962 healthy controls. MCA levels were compared with CA 125 in 70 patients with benign and 76 with malignant ovarian tumors. In addition MCA was compared with CA 15.3 in 58 patients with breast cancer and with CEA in 50 patients with colon carcinoma. In healthy controls the 95th percentile cutoff of 19.2 U/ml appeared to be higher than generally used. With the common cutoff value of 14 U/ml, a 38% sensitivity and 100% specificity was reached in malignant versus benign ovarian tumors. In colorectal cancer only 4% of patients had elevated MCA serum levels (CEA: 50%). In breast cancer patients the MCA assay performed better than CA 15.3 although only 17.2% showed elevated levels (CA 15.3: 7.4%). Thus MCA seems to be of limited value in the diagnosis and follow-up of adenocarcinomas of breast, ovary or colon.

摘要

在962名健康对照者中对黏蛋白样癌相关抗原（MCA）酶免疫测定法进行了检测。将70例良性卵巢肿瘤患者和76例恶性卵巢肿瘤患者的MCA水平与CA 125进行了比较。此外，还将58例乳腺癌患者的MCA与CA 15.3进行了比较，并将50例结肠癌患者的MCA与癌胚抗原（CEA）进行了比较。在健康对照者中，19.2 U/ml的第95百分位数临界值似乎高于通常使用的数值。采用14 U/ml的常用临界值时，在鉴别恶性与良性卵巢肿瘤方面达到了38%的灵敏度和100%的特异性。在结直肠癌患者中，仅有4%的患者血清MCA水平升高（CEA：50%）。在乳腺癌患者中，MCA检测的表现优于CA 15.3，不过仅有17.2%的患者MCA水平升高（CA 15.3：7.4%）。因此，MCA在乳腺癌、卵巢癌或结肠癌腺癌的诊断及随访中似乎价值有限。