Hallson P C, Kasidas G P, Samuell C T
Division of Molecular Pathology, University College London Medical School, UK.
Urol Int. 1996;57(1):43-7. doi: 10.1159/000282875.
The ability of three compounds, all similar in chemical structure to citric acid, to decrease calcium crystalluria has been measured. The measurements were made in normal human urine at 37 degrees C and compared with the crystal-decreasing power of citric acid when measured in the same way and in the same urine samples. One of the compounds tested, phosphocitric acid, was more potent than citric acid in inhibiting calcium oxalate crystal precipitation. At higher concentrations it also proved more effective against calcium phosphate. A urine evaporation method was used to carry out the crystal inhibition tests after modification to improve its precision.
已对三种化学结构均与柠檬酸相似的化合物减少钙结晶尿的能力进行了测定。测定是在37摄氏度的正常人尿液中进行的，并与以相同方式在相同尿液样本中测定的柠檬酸的晶体减少能力进行了比较。所测试的化合物之一——磷酸柠檬酸，在抑制草酸钙晶体沉淀方面比柠檬酸更有效。在较高浓度下，它对磷酸钙也更有效。在对一种尿液蒸发方法进行改进以提高其精度后，使用该方法进行了晶体抑制试验。
