• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

放线菌素D对核糖体RNA合成和银染色的相关抑制作用。

Correlated inhibition of ribosomal RNA synthesis and silver staining by actinomycin D.

作者信息

Hofgärtner F J, Krone W, Jain K

出版信息

Hum Genet. 1979 Apr 5;47(3):329-33. doi: 10.1007/BF00321025.

DOI:10.1007/BF00321025
PMID:88405
Abstract

Preferential inhibition of the synthesis of ribosomal RNA by low doses of actinomycin D was used to investigate the quantitative relationship between the intensity of silver staining of nucleoli and the rate of RNA-synthesis. The two parameters were found to be strongly correlated in human diploid fibroblasts.

摘要

使用低剂量放线菌素D对核糖体RNA合成的优先抑制作用来研究核仁银染强度与RNA合成速率之间的定量关系。在人二倍体成纤维细胞中发现这两个参数密切相关。

相似文献

1
Correlated inhibition of ribosomal RNA synthesis and silver staining by actinomycin D.放线菌素D对核糖体RNA合成和银染色的相关抑制作用。
Hum Genet. 1979 Apr 5;47(3):329-33. doi: 10.1007/BF00321025.
2
Repopulation of the postmitotic nucleolus by preformed RNA.通过预先形成的RNA对有丝分裂后核仁进行重新填充。
J Cell Biol. 1972 Jun;53(3):611-23. doi: 10.1083/jcb.53.3.611.
3
Incorporation of argyrophilic proteins into the nucleolus-associated chromatin caused by exposure to actinomycin D.放线菌素D暴露导致嗜银蛋白掺入核仁相关染色质。
Biol Cell. 1988;63(1):19-26.
4
[Action of actinomycin D on the nucleolar function and ultrastructure of a pig embryo kidney cell culture].[放线菌素D对猪胚胎肾细胞培养物核仁功能及超微结构的作用]
Nauchnye Doki Vyss Shkoly Biol Nauki. 1985(5):55-61.
5
Relationship between the Ag-NOR proteins and ribosomal chromatin in situ during drug-induced RNA synthesis inhibition.药物诱导的RNA合成抑制过程中原位银染核仁组织区蛋白与核糖体染色质之间的关系
J Ultrastruct Res. 1984 Jul;88(1):55-65. doi: 10.1016/s0022-5320(84)90181-3.
6
The quantitative relationship of the fibrillar centres and other nucleolar components to changes in growth conditions, serum deprivation and low doses of actinomycin D in cultured diploid human fibroblasts (strain MRC-5).原代人二倍体成纤维细胞（MRC-5株）中纤维中心及其他核仁成分与生长条件改变、血清剥夺和低剂量放线菌素D之间的定量关系。
J Cell Sci. 1981 Dec;52:373-89. doi: 10.1242/jcs.52.1.373.
7
Inhibition of nucleoplasmic transcription and the translation of rapidly labeled nuclear proteins by low concentrations of actinomycin D in vivo. Proposed role of messenger RNA in ribosomal RNA transcription.体内低浓度放线菌素D对核质转录及快速标记的核蛋白翻译的抑制作用。信使核糖核酸在核糖体核糖核酸转录中的推测作用。
Biochemistry. 1978 Apr 4;17(7):1154-60. doi: 10.1021/bi00600a003.
8
Effects of actinomycin D on ribosomal RNA and protein synthesis as revealed by high resolution autoradiography.高分辨率放射自显影揭示放线菌素D对核糖体RNA和蛋白质合成的影响。
Virchows Arch B Cell Pathol Incl Mol Pathol. 1979;31(3):251-7. doi: 10.1007/BF02889942.
9
Further studies on satellite nucleoli in rat and mouse hepatocytes.大鼠和小鼠肝细胞中卫星核仁的进一步研究。
Exp Cell Res. 1984 Mar;151(1):80-6. doi: 10.1016/0014-4827(84)90357-4.
10
Nucleoli of diploid cell strains. Thei normal ultrastructure and the effects of toyocamycin and actinomycin D.二倍体细胞株的核仁。其正常超微结构以及丰加霉素和放线菌素D的作用
J Cell Biol. 1971 Jun;49(3):785-802. doi: 10.1083/jcb.49.3.785.

引用本文的文献

1
Deoxycytidine reverses the suppression of nucleolar organizer regions' activity caused by BrdU.脱氧胞苷逆转 BrdU 引起的核仁组织者区域活性的抑制。
Theor Appl Genet. 1984 May;68(1-2):81-5. doi: 10.1007/BF00252317.
2
Influence of both coculture and BrdU on NOR activity of mouse, rat and human cells.共培养和 BrdU 对小鼠、大鼠和人细胞 NOR 活性的影响。
Theor Appl Genet. 1986 Aug;72(5):700-5. doi: 10.1007/BF00289012.
3
Reprogramming of rye rDNA in triticale during microsporogenesis.小黑麦小孢子发生过程中黑麦rDNA的重编程。

本文引用的文献

1
SEPARATION AND SOME PROPERTIES OF DISTINCT CLASSES OF MEWLY-FORMED RIBONUCLEIC ACID FROM ANIMAL CELLS.从动物细胞中分离新形成的不同类别的核糖核酸及其某些特性
Biochim Biophys Acta. 1964 Dec 16;91:678-80. doi: 10.1016/0926-6550(64)90027-1.
2
NUCLEOLAR "CAPS" PRODUCED BY ACTINOMYCIN D.放线菌素D产生的核仁“帽”
Cancer Res. 1964 Aug;24:1269-77.
3
THE EFFECT OF ACTINOMYCIN D ON THE FINE STRUCTURE OF THE NUCLEOLUS.放线菌素D对核仁精细结构的影响。
Chromosome Res. 1995 Dec;3(8):492-6. doi: 10.1007/BF00713964.
4
Evolutionary conservation of a common pattern of activity of nucleolus organizers during spermatogenesis in vertebrates.脊椎动物精子发生过程中核仁组织者常见活动模式的进化保守性。
Chromosoma. 1982;86(2):149-79. doi: 10.1007/BF00288674.
5
Silver staining of nucleolus organizer regions during human spermatogenesis.人类精子发生过程中核仁组织区的银染
Hum Genet. 1983;64(4):363-70. doi: 10.1007/BF00292368.
6
Specific silver staining of experimentally undercondensed chromosome regions.实验性凝聚不足染色体区域的特异性银染
Chromosoma. 1984;90(2):149-55. doi: 10.1007/BF00292452.
7
Observations on the dynamics of argyrophilic nucleolar material in the nuclei of mice spermatids.小鼠精子细胞细胞核中嗜银性核仁物质的动力学观察
Experientia. 1984 Sep 15;40(9):960-3. doi: 10.1007/BF01946459.
8
Drug-induced dispersal of transcribed rRNA genes and transcriptional products: immunolocalization and silver staining of different nucleolar components in rat cells treated with 5,6-dichloro-beta-D-ribofuranosylbenzimidazole.药物诱导的转录rRNA基因和转录产物的分散：用5,6-二氯-β-D-呋喃核糖基苯并咪唑处理的大鼠细胞中不同核仁成分的免疫定位和银染
J Cell Biol. 1984 Aug;99(2):672-9. doi: 10.1083/jcb.99.2.672.
9
Nucleolus organizer regions and nucleoli.核仁组织区与核仁
Hum Genet. 1983;63(2):89-99. doi: 10.1007/BF00291525.
10
Visualization of Ag-NOR proteins on nucleolar transcriptional units in molecular spreads.分子铺展中核仁转录单位上银染核仁组织区蛋白的可视化。
Chromosoma. 1982;86(5):661-72. doi: 10.1007/BF00285609.
J Ultrastruct Res. 1964 Apr;10:224-43. doi: 10.1016/s0022-5320(64)80007-1.
4
Early alterations in amino acid pools and protein synthesis of diploid fibroblasts stimulated to synthesize DNA by addition of serum.通过添加血清刺激二倍体成纤维细胞合成DNA时，其氨基酸库和蛋白质合成的早期变化。
J Cell Physiol. 1969 Oct;74(2):191-202. doi: 10.1002/jcp.1040740211.
5
Structure and synthesis of ribosomal RNA.核糖体RNA的结构与合成
Annu Rev Biochem. 1970;39:183-226. doi: 10.1146/annurev.bi.39.070170.001151.
6
Expression of human and suppression of mouse nucleolus organizer activity in mouse-human somatic cell hybrids.人核仁组织区活性在小鼠 - 人类体细胞杂种中的表达及小鼠核仁组织区活性的抑制
Proc Natl Acad Sci U S A. 1976 Dec;73(12):4531-5. doi: 10.1073/pnas.73.12.4531.
7
Evidence for postmeiotic expression of ribosomal RNA genes during male gametogenesis.雄性配子发生过程中核糖体RNA基因减数分裂后表达的证据。
Hum Genet. 1977 Oct 14;38(3):279-84. doi: 10.1007/BF00402153.
8
Activation of mouse ribosomal RNA genes at the 2-cell stage.小鼠核糖体RNA基因在二细胞阶段的激活。
Hum Genet. 1977 Aug 31;38(1):57-63. doi: 10.1007/BF00295808.
9
The nucleolar structure.核仁结构。
Int Rev Cytol. 1976;44:1-28. doi: 10.1016/s0074-7696(08)61645-9.
10
Onset of nucleolus organizer activity in early mouse embryogenesis and evidence for its regulation.小鼠胚胎早期发育过程中核仁组织区活性的起始及其调控证据
Exp Cell Res. 1978 Jul;114(2):263-8. doi: 10.1016/0014-4827(78)90482-2.