Chugh S N, Arora V, Sharma A, Chugh K
Department of Medicine & Biochemistry, Medical College & Hospital, Rohtak.
Indian J Med Res. 1996 Aug;104:190-3.
Free radicals scavengers superoxide dismuatase (SOD) and catalase and lipid peroxidation were studied in 45 patients of aluminium phosphide poisoning irrespective of age and sex admitted to a hospital in north India during the January 1992 to December 1993. Serial serum superoxide dismutase (SOD), catalase and MDA (malonyldialdehyde) were estimated on days 1, 2 and 5 post-admission depending on the survival of the patients. Serum SOD levels were significantly higher (P < 0.001) but serum catalase was significantly lower (P < 0.001) in patients than controls (patients of peripheral circulatory failure and normals) on days 1 and 2 which suggested stimulation of SOD and inhibition of catalase by phosphine resulting in excessive hydrogen peroxide (H2O2) load. Significantly higher levels of MDA (P < 0.001) in patients than controls on days 1 and 2 indicated enhanced lipid peroxidation in this poisoning. Twenty four patients died constituting a mortality rate of 53.3 per cent. The significantly high levels of SOD and MDA in non-survivors suggested their direct relation to mortality while catalase levels had an inverse relationship. Return of SOD and catalase and MDA to normal or near normal levels in survivors by day 5 suggested abolition of an oxidative stress due to elimination of phosphine.
1992年1月至1993年12月期间，对印度北部一家医院收治的45例磷化铝中毒患者（不分年龄和性别）进行了自由基清除剂超氧化物歧化酶（SOD）、过氧化氢酶以及脂质过氧化研究。根据患者的存活情况，在入院后第1天、第2天和第5天对血清超氧化物歧化酶（SOD）、过氧化氢酶和丙二醛（MDA）进行连续测定。在第1天和第2天，患者的血清SOD水平显著升高（P < 0.001），但血清过氧化氢酶水平显著降低（P < 0.001），与对照组（外周循环衰竭患者和正常人）相比，这表明磷化氢刺激了SOD并抑制了过氧化氢酶，导致过氧化氢（H2O2）负荷过高。在第1天和第2天，患者的MDA水平显著高于对照组（P < 0.001），表明该中毒情况下脂质过氧化增强。24例患者死亡，死亡率为53.3%。非存活者中SOD和MDA的显著高水平表明它们与死亡率直接相关，而过氧化氢酶水平则呈负相关。到第5天时，存活者的SOD、过氧化氢酶和MDA恢复到正常或接近正常水平，这表明由于磷化氢的消除，氧化应激得以消除。
