去甲肾上腺素对大鼠肥大细胞体外组胺释放的影响。

Effect of norepinephrine on in vitro histamine release from rat mast cells.

作者信息

Alm P E, Bloom G D

出版信息

Int Arch Allergy Appl Immunol. 1979;60(1):60-7. doi: 10.1159/000232323.

Abstract

The effect of norepinephrine on compound 48/80-induced histamine release from rat peritoneal mast cells, was studied in an in vitro system. It was found that norepinephrine, within the concentration range 10(-5)--10(-3) M, exerts a significant, dose-related, repressive effect. This effect is greatly potentiated by the beta-antagonist practolol (10(-3) M), throughout the concentration range of 10(-11)--10(-3) M norepinephrine. Methoxyamine, a selective alpha-adrenergic agonist, also represses histamine release in a dose-dependent manner; however, it is not as potent as norepinephrine. The present results would seem to suggest that the repressive effect on histamine release, observed within a low concentration range of norepinephrine, may be due to alpha-adrenoceptor mechanisms.

摘要

在体外系统中研究了去甲肾上腺素对化合物48/80诱导的大鼠腹膜肥大细胞组胺释放的影响。发现去甲肾上腺素在10^(-5) - 10^(-3) M的浓度范围内具有显著的、剂量相关的抑制作用。在10^(-11) - 10^(-3) M去甲肾上腺素的整个浓度范围内，β受体拮抗剂心得宁（10^(-3) M）可大大增强这种作用。甲氧明，一种选择性α肾上腺素能激动剂，也以剂量依赖的方式抑制组胺释放；然而，其效力不如去甲肾上腺素。目前的结果似乎表明，在去甲肾上腺素低浓度范围内观察到的对组胺释放的抑制作用可能是由于α肾上腺素能受体机制。