[秋水仙碱和秋水仙酰胺处理后有丝分裂恢复期间的蛋白质合成]
[Protein synthesis during the period of mitotic recovery following exposure to colchicine and colcemide].
作者信息
Kazan'ev E V, Zapara O M
出版信息
Biull Eksp Biol Med. 1977 May;83(5):588-9.
PMID:884267
Abstract
Autoradiographic study with leucine-3H showed the restoration of normal mitosis course after the action of colchicine on the culture of Chinese hamster cells to be accompanied by a marked activation of the protein synthesis exceeding the initial level. This intensification of protein synthesis precedes complete normalization of the mitotic activity in the cell culture. The course of normalization under the influence of colcemide is characterized only by the stabilization of the protein synthesis at the initial control level.
摘要
用氚标记的亮氨酸进行的放射自显影研究表明，秋水仙碱作用于中国仓鼠细胞培养物后，正常有丝分裂过程的恢复伴随着蛋白质合成的显著激活，超过了初始水平。蛋白质合成的这种增强先于细胞培养中有丝分裂活性的完全恢复正常。在秋水仙酰胺影响下的恢复过程仅表现为蛋白质合成稳定在初始对照水平。
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