Shekhter A B, Milovanova Z P
Arkh Patol. 1975;37(3):13-9.
Using various experimental models (postpartum involution of the uterus, resolution of a subcutaneous scar which replaced the collagen implant and connective-tissue capsule following the removal of a foreign body) and electron-microscopy and histochemical methods of investigation intra- and extracellular resorption of th e collagenous fibres was extablished. The main role in this process was played by fibroblasts which uncer these conditions could funciton as fibroclasts phagocyting and idgesting in its cytoplasma collagenous fibrillas with the help of lysosomal enzymes. Desintegration of fibroclasts, enriching the medium with these enzymes, stimulated the extracellular lysis of the collagenous fibrillas. This lysis was particularly intensive in the presence of an inflammatory process, and even could take place before the intracellular resorption. In macrophages no intracellular lysis was observed, however, they could phagocyte denaturated collagen, deprived of structural orgainzation.
利用各种实验模型（子宫产后 involution，取代胶原植入物的皮下瘢痕的消退以及异物去除后结缔组织囊）以及电子显微镜和组织化学研究方法，证实了胶原纤维的细胞内和细胞外吸收。在这个过程中起主要作用的是成纤维细胞，在这些条件下，成纤维细胞可以作为破纤维细胞发挥作用，借助溶酶体酶在其细胞质中吞噬和消化胶原纤维。破纤维细胞的解体，使培养基中富含这些酶，刺激了胶原纤维的细胞外溶解。这种溶解在炎症过程存在时特别强烈，甚至可以在细胞内吸收之前发生。在巨噬细胞中未观察到细胞内溶解，然而，它们可以吞噬变性的、缺乏结构组织的胶原。
