[Changes in the large granular vesicles in sympathetic nerve endings under the influence of several pharmacologic agents].

Electron microscopic study of large dense-core vesicles of the adrenergic nerve endings in the middle cerebral arteries of some vertebrates showed substantial changes of the vesicles studied (in comparison with control) 60 to 70 minutes after rejections of ipraside (3 mg/kg) and dopamine (40 mg/kg). A statistically significant increase of their quantity was also revealed. Large dense-core vesicles are supposed to take part in the process of accumulation and transformation of noradrenaline and/or its precursors.