Lukashin B P, Nenarokova L I
Biull Eksp Biol Med. 1977 Jun;83(6):736-8.
In experiments carried out on albino mice daily heparin injections (250 units/kg) for two weeks resulted in 30% increase of leukocyte count in the venous blood. The femur bone marrow kariocyte count remained unchanged, while the leukoerythroblastic ratio rose from 4.1 to 7.6. Autoradiography demonstrated that the duration of the mitotic cycle and its phases in myeloid cells underwent no change, constituting: T--13 hrs, ts--8 hrs, tG2--1 hour, t(G1+M)--4 hrs. In heparinized animals the curve of labeled mitoses was nearly ideal. It is suggested that there occurred a change in the stem cells differentiation towards the myeloid type in the bone marrow under the effect of heparin.
在对白化小鼠进行的实验中，每日注射肝素（250单位/千克），持续两周，导致静脉血白细胞计数增加30%。股骨骨髓有核细胞计数保持不变，而粒红比例从4.1升至7.6。放射自显影显示，髓细胞有丝分裂周期及其各阶段的持续时间没有变化，分别为：T期——13小时，ts期——8小时，tG2期——1小时，t（G1+M）期——4小时。在注射肝素的动物中，标记有丝分裂曲线近乎理想。提示在肝素作用下，骨髓中干细胞向髓细胞类型的分化发生了改变。
