Teterina V I, Pichugina T V, Kolmogorova L A, Gol'dberg E D
Antibiotiki. 1980 Oct;25(10):760-4.
Autoradiographic investigations with the use of 3H-thymidine were performed on 140 noninbred albino rats. The fate of the label in the cells of the myeloid series was followed in the experimental and control groups. The animals of the experimental group were treated with carminomycin in the LD50 30 minutes after injecion of 3H-thymidine. The mitotic cycle of the nondifferentiated cells and promyelocytes + myelocytes in the control animals was equal to 24 hours, the period and rate of the metamyelocyte maturation being 10 hours and 0.81 per cent/hour respectively. The mitotic cycle of the nondifferentiated cells and promyelocytes + myelocytes during the first division after carminomycin administration increased up to 48 hours due to the block of G2-period, the period and rate of the metamyelocyte maturation being 18 hours and 0.43 per cent/hour respectively. The myelotoxic effect of carminomycin was due to the damage of the dividing cells in G2-period of the mitotic cycle, decreased rate of differentiation and death of the cells after or during the first and second divisions.
对140只非近交系白化大鼠进行了使用³H-胸腺嘧啶核苷的放射自显影研究。在实验组和对照组中追踪了髓系细胞中标记物的命运。实验组动物在注射³H-胸腺嘧啶核苷30分钟后，用卡米诺霉素以半数致死量进行处理。对照组动物中未分化细胞以及早幼粒细胞+中幼粒细胞的有丝分裂周期为24小时，晚幼粒细胞成熟的时间和速率分别为10小时和0.81%/小时。在给予卡米诺霉素后的首次分裂期间，未分化细胞以及早幼粒细胞+中幼粒细胞的有丝分裂周期因G2期受阻而延长至48小时，晚幼粒细胞成熟的时间和速率分别为18小时和0.43%/小时。卡米诺霉素的骨髓毒性作用是由于有丝分裂周期G2期的分裂细胞受损、分化速率降低以及细胞在首次和第二次分裂后或期间死亡所致。
