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本文引用的文献

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Characterization of beta-lactamase gene blaPER-2, which encodes an extended-spectrum class A beta-lactamase.编码超广谱A类β-内酰胺酶的β-内酰胺酶基因blaPER-2的特征分析。
Antimicrob Agents Chemother. 1996 Mar;40(3):616-20. doi: 10.1128/AAC.40.3.616.
2
Characterization of the plasmidic beta-lactamase CMY-2, which is responsible for cephamycin resistance.负责头孢霉素耐药性的质粒β-内酰胺酶CMY-2的特性分析。
Antimicrob Agents Chemother. 1996 Jan;40(1):221-4. doi: 10.1128/AAC.40.1.221.
3
Plasmid-mediated AmpC-type beta-lactamase isolated from Klebsiella pneumoniae confers resistance to broad-spectrum beta-lactams, including moxalactam.从肺炎克雷伯菌中分离出的质粒介导的AmpC型β-内酰胺酶可赋予对包括莫西沙星在内的广谱β-内酰胺类抗生素的耐药性。
Antimicrob Agents Chemother. 1993 May;37(5):984-90. doi: 10.1128/AAC.37.5.984.
4
Characterization of a novel extended-spectrum beta-lactamase from Pseudomonas aeruginosa.铜绿假单胞菌新型超广谱β-内酰胺酶的特性分析
Antimicrob Agents Chemother. 1993 May;37(5):962-9. doi: 10.1128/AAC.37.5.962.
5
Identification of a novel plasmid-mediated beta-lactamase with chromosomal cephalosporinase characteristics from Klebsiella pneumoniae.从肺炎克雷伯菌中鉴定出一种具有染色体头孢菌素酶特性的新型质粒介导的β-内酰胺酶。
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6
Characterization of a plasmid-borne and constitutively expressed blaMOX-1 gene encoding AmpC-type beta-lactamase.编码AmpC型β-内酰胺酶的质粒携带型组成型表达blaMOX-1基因的特性分析
Gene. 1994 Feb 11;139(1):93-8. doi: 10.1016/0378-1119(94)90529-0.
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Cloning and sequence analysis of blaBIL-1, a plasmid-mediated class C beta-lactamase gene in Escherichia coli BS.大肠杆菌BS中质粒介导的C类β-内酰胺酶基因blaBIL-1的克隆与序列分析
Antimicrob Agents Chemother. 1994 May;38(5):1182-5. doi: 10.1128/AAC.38.5.1182.
8
Gene sequence and biochemical characterization of FOX-1 from Klebsiella pneumoniae, a new AmpC-type plasmid-mediated beta-lactamase with two molecular variants.肺炎克雷伯菌中FOX-1的基因序列和生化特性，一种具有两种分子变体的新型AmpC型质粒介导的β-内酰胺酶。
Antimicrob Agents Chemother. 1994 Sep;38(9):2150-7. doi: 10.1128/AAC.38.9.2150.
9
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Antimicrob Agents Chemother. 1995 Jun;39(6):1211-33. doi: 10.1128/AAC.39.6.1211.
10
ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type.大肠杆菌K-12的AmpC头孢菌素酶与青霉素酶型β-内酰胺酶有着不同的进化起源。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4897-901. doi: 10.1073/pnas.78.8.4897.

头孢菌素酶blaCMY-1基因的比较特征及其与其他β-内酰胺酶基因的关系。

Comparative characterization of the cephamycinase blaCMY-1 gene and its relationship with other beta-lactamase genes.

作者信息

Bauernfeind A, Stemplinger I, Jungwirth R, Wilhelm R, Chong Y

机构信息

Max von Pettenkofer-Institut, München, Federal Republic of Germany.

出版信息

Antimicrob Agents Chemother. 1996 Aug;40(8):1926-30. doi: 10.1128/AAC.40.8.1926.

DOI:10.1128/AAC.40.8.1926
PMID:8843306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC163442/
Abstract

A plasmidic beta-lactamase which hydrolyzed cephamycins was first detected and reported in 1989. At that time its description was restricted to phenotypic characteristics. We analyzed nucleotide sequence of its gene and explored it genetic relationship with other bla genes. The deduced amino acid sequence of the blaCMY-1 product was compared with those of other known plasmidic cephamycinases and of chromosomal AmpC beta-lactamases. The results indicate that the relationship of CMY-1 is closest to MOX-1 among the plasmidic cephamycinases and to AmpC of Pseudomonas aeruginosa among the chromosomal cephalosporinases. We conclude that the plasmidic cephamycinases described up to now may be classified into three families, as follows: CMY-1, MOX-1, and FOX-1 with AmpC of P. aeruginosa; CMY-2, BIL-1 and LAT-1 with AmpC of Citrobacter freundii; and MIR-1 with AmpC of Enterobacter cloacae. Plasmidic cephamycinases are now recognized as clinically relevant class C beta-lactamases.

摘要

1989年首次检测并报道了一种可水解头霉素的质粒β-内酰胺酶。当时对它的描述仅限于表型特征。我们分析了其基因的核苷酸序列，并探究了它与其他bla基因的遗传关系。将blaCMY-1产物推导的氨基酸序列与其他已知的质粒头霉素酶以及染色体AmpCβ-内酰胺酶的氨基酸序列进行了比较。结果表明，在质粒头霉素酶中，CMY-1与MOX-1的关系最为密切；在染色体头孢菌素酶中，CMY-1与铜绿假单胞菌的AmpC关系最为密切。我们得出结论，目前已描述的质粒头霉素酶可分为三个家族，如下：与铜绿假单胞菌AmpC相关的CMY-1、MOX-1和FOX-1；与弗氏柠檬酸杆菌AmpC相关的CMY-2、BIL-1和LAT-1；以及与阴沟肠杆菌AmpC相关的MIR-1。质粒头霉素酶现已被公认为临床上相关的C类β-内酰胺酶。