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2
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本文引用的文献

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Identification of a novel plasmid-mediated beta-lactamase with chromosomal cephalosporinase characteristics from Klebsiella pneumoniae.从肺炎克雷伯菌中鉴定出一种具有染色体头孢菌素酶特性的新型质粒介导的β-内酰胺酶。
J Antimicrob Chemother. 1993 May;31(5):645-54. doi: 10.1093/jac/31.5.645.
2
Characterization of a plasmid-borne and constitutively expressed blaMOX-1 gene encoding AmpC-type beta-lactamase.编码AmpC型β-内酰胺酶的质粒携带型组成型表达blaMOX-1基因的特性分析
Gene. 1994 Feb 11;139(1):93-8. doi: 10.1016/0378-1119(94)90529-0.
3
Cloning and sequence analysis of blaBIL-1, a plasmid-mediated class C beta-lactamase gene in Escherichia coli BS.大肠杆菌BS中质粒介导的C类β-内酰胺酶基因blaBIL-1的克隆与序列分析
Antimicrob Agents Chemother. 1994 May;38(5):1182-5. doi: 10.1128/AAC.38.5.1182.
4
Gene sequence and biochemical characterization of FOX-1 from Klebsiella pneumoniae, a new AmpC-type plasmid-mediated beta-lactamase with two molecular variants.肺炎克雷伯菌中FOX-1的基因序列和生化特性，一种具有两种分子变体的新型AmpC型质粒介导的β-内酰胺酶。
Antimicrob Agents Chemother. 1994 Sep;38(9):2150-7. doi: 10.1128/AAC.38.9.2150.
5
A functional classification scheme for beta-lactamases and its correlation with molecular structure.β-内酰胺酶的功能分类方案及其与分子结构的相关性。
Antimicrob Agents Chemother. 1995 Jun;39(6):1211-33. doi: 10.1128/AAC.39.6.1211.
6
ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type.大肠杆菌K-12的AmpC头孢菌素酶与青霉素酶型β-内酰胺酶有着不同的进化起源。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4897-901. doi: 10.1073/pnas.78.8.4897.
7
The structure of beta-lactamases.β-内酰胺酶的结构
Philos Trans R Soc Lond B Biol Sci. 1980 May 16;289(1036):321-31. doi: 10.1098/rstb.1980.0049.
8
Biochemical characterization of type A and type B beta-lactamase from Enterobacter cloacae.阴沟肠杆菌 A 型和 B 型β-内酰胺酶的生化特性
Rev Infect Dis. 1988 Jul-Aug;10(4):714-20. doi: 10.1093/clinids/10.4.714.
9
Fast and sensitive multiple sequence alignments on a microcomputer.在微型计算机上进行快速且灵敏的多序列比对。
Comput Appl Biosci. 1989 Apr;5(2):151-3. doi: 10.1093/bioinformatics/5.2.151.
10
Extended broad spectrum beta-lactamase in Klebsiella pneumoniae including resistance to cephamycins.肺炎克雷伯菌中的超广谱β-内酰胺酶，包括对头孢霉素的耐药性。
Infection. 1989 Sep-Oct;17(5):316-21. doi: 10.1007/BF01650718.

负责头孢霉素耐药性的质粒β-内酰胺酶CMY-2的特性分析。

Characterization of the plasmidic beta-lactamase CMY-2, which is responsible for cephamycin resistance.

作者信息

Bauernfeind A, Stemplinger I, Jungwirth R, Giamarellou H

机构信息

Max von Pettenkofer-Institut, Munich, Germany.

出版信息

Antimicrob Agents Chemother. 1996 Jan;40(1):221-4. doi: 10.1128/AAC.40.1.221.

DOI:10.1128/AAC.40.1.221
PMID:8787910
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC163087/
Abstract

The phenotype of Klebsiella pneumoniae HEL-1 indicates a plasmidic cephamycinase gene (blaCMY-2). Its sequence shows one open reading frame coding for a protein of 381 amino acids. CMY-2 is classified as class C beta-lactamase that is closely related to the plasmidic enzymes BIL-1 and LAT-1 and the chromosomal AmpC of Citrobacter freundii. The blaCMY-2 gene possibly was translocated onto a plasmid of C. freundii which spread to K. pneumoniae.

摘要

肺炎克雷伯菌HEL-1的表型表明存在一个质粒头孢菌素酶基因（blaCMY-2）。其序列显示一个开放阅读框，编码一种由381个氨基酸组成的蛋白质。CMY-2被归类为C类β-内酰胺酶，与质粒酶BIL-1和LAT-1以及弗氏柠檬酸杆菌的染色体AmpC密切相关。blaCMY-2基因可能转移到了弗氏柠檬酸杆菌的一个质粒上，该质粒传播到了肺炎克雷伯菌。