运动神经元对电泳施加多巴胺的反应。
Responses of motoneurones to electrophoretically applied dopamine.
作者信息
Barasi S, Roberts M T
出版信息
Br J Pharmacol. 1977 May;60(1):29-34. doi: 10.1111/j.1476-5381.1977.tb16743.x.
Abstract
- The effect of electrophoretically applied dopamine upon motoneurone excitability has been investigated. Field potentials originating from antidromically activated motoneurones were recorded from the ventral horn of the rat lumbar spinal cord. 2. Field potentials showed an increase in amplitude following electrophoretic application of dopamine. Dopamine was shown to be less potent than noradrenaline and 5-hydroxytryptamine in producing these changes. 3. Measurement of the transport number of dopamine suggest that the relatively low potency of dopamine cannot be attributed to differences in ionic mobilities between the amines. 4. Electrophoretic application of alpha-flupenthixol was shown to discriminate between dopamine and 5-hydroxytryptamine responses. Dopamine responses were profoundly reduced. 5. Electrophoretically applied alpha-flupenthixol also discriminated between dopamine and noradrenaline. Noradrenaline responses were consistently potentiated by alpha-flupenthixol. The possibility is discussed that dopamine may not merely be a precursor for noradrenaline in the rat spinal cord.
摘要
- 研究了电泳施加多巴胺对运动神经元兴奋性的影响。从大鼠腰段脊髓腹角记录源自逆向激活运动神经元的场电位。2. 场电位在电泳施加多巴胺后振幅增加。结果表明，在产生这些变化方面，多巴胺的效力低于去甲肾上腺素和5-羟色胺。3. 多巴胺迁移数的测量表明，多巴胺效力相对较低不能归因于胺类之间离子迁移率的差异。4. 电泳施加α-氟哌噻吨可区分多巴胺和5-羟色胺反应。多巴胺反应显著降低。5. 电泳施加α-氟哌噻吨也可区分多巴胺和去甲肾上腺素。α-氟哌噻吨可使去甲肾上腺素反应持续增强。文中讨论了多巴胺在大鼠脊髓中可能不仅仅是去甲肾上腺素前体的可能性。
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