Rock E, Astier C, Lab C, Malpuech C, Nowacki W, Gueux E, Mazur A, Rayssiguier Y
Laboratoire des Maladies Métaboliques, I.N.R.A., St-Genès-Champanelle, France.
Magnes Res. 1995 Sep;8(3):237-42.
Magnesium deficiency in rats leads to an oxidative stress involving an increased production of radical oxygen species. The present study was designed to examine the effect of experimental magnesium deficiency on plasma nitric oxide (NO) level and nitric oxide synthases (NOS) activities in rats. The data show that the concentration of NO is markedly increased in plasma of magnesium-deficient rats. This rise in plasma NO results from activation of inducible nitric oxide synthase (iNOS) rather than of the constitutive form (cNOS) of the enzyme. These data are in agreement with previous observations indicating that inflammation occurs during magnesium-deficiency and provide an additional cause of oxidative lesions through formation of peroxynitrite from nitric oxide and superoxide anion.
大鼠体内镁缺乏会导致氧化应激，使活性氧的产生增加。本研究旨在检测实验性镁缺乏对大鼠血浆一氧化氮（NO）水平及一氧化氮合酶（NOS）活性的影响。数据显示，缺镁大鼠血浆中NO浓度显著升高。血浆中NO的这种升高是由诱导型一氧化氮合酶（iNOS）而非该酶的组成型（cNOS）激活所致。这些数据与先前的观察结果一致，即镁缺乏时会发生炎症，并通过一氧化氮与超氧阴离子形成过氧亚硝酸盐为氧化损伤提供了另一个原因。
