Human Nutrition Unit, Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, University Hospital of Sant Joan de Reus, Pere Virgili Institute for Health Research, Rovira i Virgili University, St/Sant Llorenç 21, 43201 Reus, Spain.
CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Nutrients. 2018 Feb 1;10(2):168. doi: 10.3390/nu10020168.
Magnesium (Mg) is an essential dietary element for humans involved in key biological processes. A growing body of evidence from epidemiological studies, randomized controlled trials (RCTs) and meta-analyses have indicated inverse associations between Mg intake and cardiovascular diseases (CVD). The present review aims to summarize recent scientific evidence on the topic, with a focus on data from epidemiological studies assessing the associations between Mg intake and major cardiovascular (CV) risk factors and CVD. We also aimed to review current literature on circulating Mg and CVD, as well as potential biological processes underlying these observations. We concluded that high Mg intake is associated with lower risk of major CV risk factors (mainly metabolic syndrome, diabetes and hypertension), stroke and total CVD. Higher levels of circulating Mg are associated with lower risk of CVD, mainly ischemic heart disease and coronary heart disease. Further, RCTs and prospective studies would help to clarify whether Mg intake and Mg circulating levels may also protect against other CVDs and CVD death.
镁（Mg）是人体必需的膳食元素，参与关键的生物过程。越来越多的流行病学研究、随机对照试验（RCT）和荟萃分析的证据表明，镁摄入量与心血管疾病（CVD）呈负相关。本综述旨在总结这一主题的最新科学证据，重点关注评估镁摄入量与主要心血管（CV）风险因素和 CVD 之间关系的流行病学研究数据。我们还旨在回顾当前关于循环镁和 CVD 的文献，以及这些观察结果背后的潜在生物学过程。我们得出结论，高镁摄入量与主要 CV 风险因素（主要是代谢综合征、糖尿病和高血压）、中风和总 CVD 的风险降低有关。较高的循环镁水平与 CVD 的风险降低有关，主要是缺血性心脏病和冠心病。此外，RCT 和前瞻性研究将有助于阐明镁摄入量和循环镁水平是否也可以预防其他 CVD 和 CVD 死亡。
