Kosugi H, Asano Y, Nagayama T, Beppu M, Kikugawa K
Ferris University, Yokohama, Japan.
Biol Pharm Bull. 1995 Sep;18(9):1275-8. doi: 10.1248/bpb.18.1275.
The level of urinary thiobarbituric acid reactive substances (TBARS) consisting of bound forms of malonaldehyde and, to a lesser extent, other aldehydes is one of the indices of lipid peroxidation status. Levels of urinary TBARS in healthy subjects before and after supplementation with a high dose of d-alpha-tocopherol were measured using high performance liquid chromatography. Four healthy Japanese were given a supplement of 300 mg d-alpha-tocopherol/d, about 40-fold higher than the normal intake recommended, for a period of 50 d. Levels of urinary TBARS (nmol/kg body weight.h) within-day, before and after supplementation with d-alpha-tocopherol, exhibited similar behavior and levels of daily urinary TBARS (nmol/kg body weight.d) were unchanged by d-alpha-tocopherol supplementation. These results indicate that supplementation with a high dose of d-alpha-tocopherol does not affect the level of urinary TBARS.
由丙二醛结合形式以及少量其他醛类组成的尿硫代巴比妥酸反应性物质（TBARS）水平是脂质过氧化状态指标之一。采用高效液相色谱法测定了健康受试者在补充高剂量d-α-生育酚前后的尿TBARS水平。四名健康日本人连续50天每天补充300 mg d-α-生育酚，这一剂量约为推荐正常摄入量的40倍。补充d-α-生育酚前后，日内尿TBARS水平（nmol/kg体重·小时）表现出相似的变化趋势，且补充d-α-生育酚后每日尿TBARS水平（nmol/kg体重·天）未发生改变。这些结果表明，补充高剂量d-α-生育酚不会影响尿TBARS水平。
