Wu D C, Schwartz B, Schwoerer J, Banwatt R
Tufts University School of Medicine, Boston, MA, USA.
Acta Ophthalmol Scand Suppl. 1995(215):33-40. doi: 10.1111/j.1600-0420.1995.tb00590.x.
The purpose of this paper was to develop a technique using computerized image analysis to measure the width of retinal arteries and veins on color fundus photographs. The width of the retinal vessel was determined from digitized fundus photographs by programs based on edge detection and boundary tracing. The average vessel width was determined at different distances or eccentricities from the center of the optic disc and using various lengths of vessel segment. Measurements of superior and inferior temporal vessel width for 20 eyes by 2 operators showed that about 75% of the measurements could be obtained without the use of plan points. The average percent coefficient of variation of the measurements was 2.17% for 3 measurements of each vessel. This technique provides a reproducible and objective method for obtaining the following parameters: the edges of the vessel, the length of the vessel segment to be measured, location of the measurement along the vessel and subsequent retinal vessel width. This technique is readily suitable for application to clinical studies particularly clinical trials.
本文的目的是开发一种利用计算机图像分析技术来测量彩色眼底照片上视网膜动静脉宽度的方法。视网膜血管宽度是通过基于边缘检测和边界追踪的程序从数字化眼底照片中确定的。平均血管宽度是在距视盘中心不同距离或偏心度处，并使用不同长度的血管段来确定的。两名操作者对20只眼睛的颞上和颞下血管宽度进行测量，结果显示约75%的测量无需使用标点即可获得。每条血管3次测量的平均测量变异系数百分比为2.17%。该技术为获取以下参数提供了一种可重复且客观的方法：血管边缘、待测血管段长度、沿血管的测量位置以及随后的视网膜血管宽度。该技术很适合应用于临床研究，尤其是临床试验。
