Isenberg D A
Bloomsbury Rheumatology Unit/Division of Rheumatology, Department of Medicine, University College London, UK.
Clin Exp Rheumatol. 1995 Sep-Oct;13 Suppl 12:S17-20.
Humoral abnormalities are a significant feature of rheumatoid arthritis (RA) even if, as seems likely, they do not represent primary phenomena. Thus, autoantibodies including rheumatoid factor, anti-perinuclear factor and anti-RA33 antibodies are important serological features of RA, although none are truly disease-specific. In addition, it has been shown that serum IgGs from RA have an increased number of oligosaccharide structures attached to the Fc region whose outer 'arms' lack galactose [i.e. increased Gal (0)]. Measurement of Gal (0) has been shown to have clinical utility in the assessment and follow-up of patients with RA.
体液异常是类风湿性关节炎（RA）的一个显著特征，即便它们可能并非原发性现象。因此，包括类风湿因子、抗核周因子及抗RA33抗体在内的自身抗体是RA重要的血清学特征，尽管没有一种抗体是RA真正特有的。此外，研究表明，RA患者血清IgG在Fc区连接的寡糖结构数量增加，其外侧“臂”缺乏半乳糖[即半乳糖缺失（Gal(0)）增加]。半乳糖缺失（Gal(0)）的检测已显示在RA患者的评估及随访中具有临床应用价值。
