Angelides S, Lee F T, Basten A, Lambrecht R M, Walker K Z, Bundesen P G, Bautovich G J
Department of Nuclear Medicine, Royal Prince Alfred Hospital, Sydney, Australia.
Clin Nucl Med. 1996 Mar;21(3):242-4. doi: 10.1097/00003072-199603000-00011.
The authors present the case studies of two patients whose malignant tumors were detected with a Tc-99m labeled antifibrin monoclonal antibody (DD-3B6/22), which is specific for cross-linked fibrin. The first case was a malignant fibrous histiocytoma involving the proximal aspect of the left thigh, whereas in the second case, the patient was receiving treatment for a squamous cell carcinoma of the right mainstem bronchus. The results highlight the potential of this anti-D-dimer radiopharmaceutical for noninvasive detection of malignant tumors.
作者介绍了两名患者的病例研究，这两名患者的恶性肿瘤是用一种对交联纤维蛋白具有特异性的锝-99m标记抗纤维蛋白单克隆抗体（DD-3B6/22）检测到的。第一例是累及左大腿近端的恶性纤维组织细胞瘤，而第二例患者正在接受右主支气管鳞状细胞癌的治疗。结果突出了这种抗D-二聚体放射性药物在恶性肿瘤无创检测方面的潜力。
