Cheverud J M, Routman E J, Duarte F A, van Swinderen B, Cothran K, Perel C
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Genetics. 1996 Apr;142(4):1305-19. doi: 10.1093/genetics/142.4.1305.
Body size is an archetypal quantitative trait with variation due to the segregation of many gene loci, each of relatively minor effect, and the environment. We examine the effects of quantitative trait loci (QTLs) on age-specific body weights and growth in the F2 intercross of the LG/J and SM/J strains of inbred mice. Weekly weights (1-10 wk) and 75 microsatellite genotypes were obtained for 535 mice. Interval mapping was used to locate and measure the genotypic effects of QTLs on body weight and growth. QTL effects were detected on 16 of the 19 autosomes with several chromosomes carrying more than one QTL. The number of QTLs for age-specific weights varied from seven at 1 week to 17 at 10 wk. The QTLs were each of relatively minor, subequal effect. QTLs affecting early and late growth were generally distinct, mapping to different chromosomal locations indicating separate genetic and physiological systems for early and later murine growth.
体型是一种典型的数量性状，其变异源于许多基因位点的分离，每个基因位点的效应相对较小，同时也受环境影响。我们研究了数量性状基因座（QTL）对近交系小鼠LG/J和SM/J品系F2杂交后代特定年龄体重和生长的影响。获取了535只小鼠的每周体重（1 - 10周）和75个微卫星基因型。采用区间作图法来定位和测量QTL对体重和生长的基因型效应。在19条常染色体中的16条上检测到了QTL效应，几条染色体携带不止一个QTL。特定年龄体重的QTL数量从1周龄时的7个到10周龄时的17个不等。每个QTL的效应相对较小且大致相等。影响早期和晚期生长的QTL通常是不同的，定位于不同的染色体位置，表明小鼠早期和晚期生长存在独立的遗传和生理系统。
