Suppr超能文献

小鼠生长的数量性状基因座

Quantitative trait loci for murine growth.

作者信息

Cheverud J M, Routman E J, Duarte F A, van Swinderen B, Cothran K, Perel C

机构信息

Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

出版信息

Genetics. 1996 Apr;142(4):1305-19. doi: 10.1093/genetics/142.4.1305.

DOI:10.1093/genetics/142.4.1305
PMID:8846907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1207127/
Abstract

Body size is an archetypal quantitative trait with variation due to the segregation of many gene loci, each of relatively minor effect, and the environment. We examine the effects of quantitative trait loci (QTLs) on age-specific body weights and growth in the F2 intercross of the LG/J and SM/J strains of inbred mice. Weekly weights (1-10 wk) and 75 microsatellite genotypes were obtained for 535 mice. Interval mapping was used to locate and measure the genotypic effects of QTLs on body weight and growth. QTL effects were detected on 16 of the 19 autosomes with several chromosomes carrying more than one QTL. The number of QTLs for age-specific weights varied from seven at 1 week to 17 at 10 wk. The QTLs were each of relatively minor, subequal effect. QTLs affecting early and late growth were generally distinct, mapping to different chromosomal locations indicating separate genetic and physiological systems for early and later murine growth.

摘要

体型是一种典型的数量性状，其变异源于许多基因位点的分离，每个基因位点的效应相对较小，同时也受环境影响。我们研究了数量性状基因座（QTL）对近交系小鼠LG/J和SM/J品系F2杂交后代特定年龄体重和生长的影响。获取了535只小鼠的每周体重（1 - 10周）和75个微卫星基因型。采用区间作图法来定位和测量QTL对体重和生长的基因型效应。在19条常染色体中的16条上检测到了QTL效应，几条染色体携带不止一个QTL。特定年龄体重的QTL数量从1周龄时的7个到10周龄时的17个不等。每个QTL的效应相对较小且大致相等。影响早期和晚期生长的QTL通常是不同的，定位于不同的染色体位置，表明小鼠早期和晚期生长存在独立的遗传和生理系统。

相似文献

1
Quantitative trait loci for murine growth.
Genetics. 1996 Apr;142(4):1305-19. doi: 10.1093/genetics/142.4.1305.
2
Mapping quantitative trait loci for murine growth: a closer look at genetic architecture.
Genet Res. 1999 Dec;74(3):313-22. doi: 10.1017/s0016672399004103.
3
Genetic architecture of adiposity in the cross of LG/J and SM/J inbred mice.
Mamm Genome. 2001 Jan;12(1):3-12. doi: 10.1007/s003350010218.
4
Quantitative trait loci for body weight in the intercross between SM/J and A/J mice.
Exp Anim. 2001 Jul;50(4):319-24. doi: 10.1538/expanim.50.319.
5
Multiple-trait QTL mapping for body and organ weights in a cross between NMRI8 and DBA/2 mice.
Genet Res. 2007 Feb;89(1):47-59. doi: 10.1017/S001667230700852X.
6
Further mapping of quantitative trait loci for postnatal growth in an inter-sub-specific backcross of wild Mus musculus castaneus and C57BL/6J mice.
Genet Res. 2005 Apr;85(2):127-37. doi: 10.1017/S001667230500738X.
7
Fine-mapping alleles for body weight in LG/J × SM/J F₂ and F(34) advanced intercross lines.
Mamm Genome. 2011 Oct;22(9-10):563-71. doi: 10.1007/s00335-011-9349-z. Epub 2011 Jul 15.
8
Body Composition QTLs Identified in Intercross Populations Are Reproducible in Consomic Mouse Strains.
PLoS One. 2015 Nov 9;10(11):e0141494. doi: 10.1371/journal.pone.0141494. eCollection 2015.
9
Pleiotropic effects on mandibular morphology II: differential epistasis and genetic variation in morphological integration.
J Exp Zool B Mol Dev Evol. 2004 Sep 15;302(5):424-35. doi: 10.1002/jez.b.21008.
10
Quantitative trait loci (QTLs) mapping for growth traits in the mouse: a review.
Genet Sel Evol. 2001 Mar-Apr;33(2):105-32. doi: 10.1186/1297-9686-33-2-105.

引用本文的文献

1
Gene-by-environment Interactions and Adaptive Body Size Variation in Mice From the Americas.
Mol Biol Evol. 2025 Apr 1;42(4). doi: 10.1093/molbev/msaf078.
2
Dissecting the Complexity of Skeletal-Malocclusion-Associated Phenotypes: Mouse for the Rescue.
Int J Mol Sci. 2023 Jan 29;24(3):2570. doi: 10.3390/ijms24032570.
3
Age and diet shape the genetic architecture of body weight in diversity outbred mice.
Elife. 2022 Jul 15;11:e64329. doi: 10.7554/eLife.64329.
4
Effects of kinship correction on inflation of genetic interaction statistics in commonly used mouse populations.
G3 (Bethesda). 2021 Jul 14;11(7). doi: 10.1093/g3journal/jkab131.
5
Studies on the Small Body Size Mouse Developed by Mutagen -Ethyl--nitrosourea.
Toxicol Res. 2008 Mar;24(1):69-78. doi: 10.5487/TR.2008.24.1.069. Epub 2008 Mar 1.
6
Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2.
Am J Hum Genet. 2019 Dec 5;105(6):1222-1236. doi: 10.1016/j.ajhg.2019.10.014. Epub 2019 Nov 21.
7
Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice.
Animal Model Exp Med. 2018 Oct 24;1(3):212-220. doi: 10.1002/ame2.12036. eCollection 2018 Sep.
8
FoxO6 regulates Hippo signaling and growth of the craniofacial complex.
PLoS Genet. 2018 Oct 4;14(10):e1007675. doi: 10.1371/journal.pgen.1007675. eCollection 2018 Oct.
9
Replication and discovery of musculoskeletal QTLs in LG/J and SM/J advanced intercross lines.
Physiol Rep. 2018 Feb;6(4). doi: 10.14814/phy2.13561.
10
Adiposity QTL Adip20 decomposes into at least four loci when dissected using congenic strains.
PLoS One. 2017 Dec 1;12(12):e0188972. doi: 10.1371/journal.pone.0188972. eCollection 2017.

本文引用的文献

1
PROGRESS REPORT ON POSSIBILITIES IN PROGENY-TEST BREEDING.
Science. 1941 Nov 7;94(2445):442-3. doi: 10.1126/science.94.2445.442.
2
Analysis of Quantitative Inheritance of Body Size in Mice. I. Hybridization and Maternal Influence.
Genetics. 1956 Mar;41(2):157-64. doi: 10.1093/genetics/41.2.157.
3
REGULATION OF GROWTH IN SIZE IN MAMMALS.
Nature. 1963 Aug 31;199:845-50. doi: 10.1038/199845a0.
4
A rapid method of scoring simple sequence repeat polymorphisms with agarose gel electrophoresis.
Mamm Genome. 1994 Mar;5(3):187-8. doi: 10.1007/BF00352355.
5
Genetic dissection of complex traits.
Science. 1994 Sep 30;265(5181):2037-48. doi: 10.1126/science.8091226.
6
Precision mapping of quantitative trait loci.
Genetics. 1994 Apr;136(4):1457-68. doi: 10.1093/genetics/136.4.1457.
7
A genetic map of the mouse with 4,006 simple sequence length polymorphisms.
Nat Genet. 1994 Jun;7(2 Spec No):220-45. doi: 10.1038/ng0694supp-220.
8
Polymorphism for PCR-analyzed microsatellites between the inbred mouse strains LG and SM.
Mamm Genome. 1995 Jun;6(6):401-4. doi: 10.1007/BF00355640.
9
A genetic analysis of targeted growth in mice.
Genetics. 1984 May;107(1):79-101. doi: 10.1093/genetics/107.1.79.
10
Quantitative genetics and the evolution of ontogeny. II. Genetic and environmental correlations among age-specific characters in randombred house mice.
Growth. 1984 Autumn;48(3):339-53.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验