Lysle D T, Coussons-Read M E
Department of Psychology, University of North Carolina at Chapel Hill 27599-3270, USA.
Int J Immunopharmacol. 1995 Aug;17(8):641-7. doi: 10.1016/0192-0561(95)00050-c.
This article presents some recent work from our laboratory indicating that multiple physiological systems play a role in conditioned immunomodulation. The first study shows that naltrexone, but not N-methylnaltrexone, blocks the suppressive effects of an aversive conditioned stimulus on Con-A-induced proliferation and natural killer cell activity of splenic lymphocytes. This finding indicates that central opioid activity is involved in the conditioned effects. The second study shows that the beta-adrenergic antagonists atenolol and ICI-118,551 block of the suppressive effects of an aversive conditioned stimulus on Con-A-induced proliferation, but have no effect on natural killer cell activity. This result indicates the involvement of the adrenergic system in a subset of the conditioned effects. Collectively, these experiments provide evidence that both the opioid system and the sympathetic nervous system are involved in conditioned immunomodulatory changes elicited by an aversive conditioned stimulus.
本文展示了我们实验室最近的一些研究成果，表明多种生理系统在条件性免疫调节中发挥作用。第一项研究表明，纳曲酮而非N-甲基纳曲酮可阻断厌恶条件刺激对脾淋巴细胞Con-A诱导增殖和自然杀伤细胞活性的抑制作用。这一发现表明中枢阿片类活性参与了条件性效应。第二项研究表明，β-肾上腺素能拮抗剂阿替洛尔和ICI-118,551可阻断厌恶条件刺激对Con-A诱导增殖的抑制作用，但对自然杀伤细胞活性无影响。这一结果表明肾上腺素能系统参与了部分条件性效应。总体而言，这些实验提供了证据，证明阿片类系统和交感神经系统均参与了由厌恶条件刺激引发的条件性免疫调节变化。
