鸟氨酸脱羧酶抗酶：一种新型调节蛋白。
Ornithine decarboxylase antizyme: a novel type of regulatory protein.
作者信息
Hayashi S, Murakami Y, Matsufuji S
机构信息
Department of Biochemistry II, Jikei University School of Medicine, Tokyo, Japan.
出版信息
Trends Biochem Sci. 1996 Jan;21(1):27-30.
PMID:8848835
Abstract
Antizyme plays an important regulatory role in the synthesis of ornithine decarboxylase (ODC), a key enzyme of polyamine synthesis in higher animals. As well as inactivating polyamine uptake, antizyme is induced by polyamine-enhanced translational frameshifting, and binds to ODC, accelerating its ATP-dependent degradation, a process catalysed by the 26S proteasome.
摘要
抗酶在高等动物多胺合成的关键酶——鸟氨酸脱羧酶（ODC）的合成中发挥着重要的调节作用。除了使多胺摄取失活外，抗酶还由多胺增强的翻译移码诱导产生，并与ODC结合，加速其依赖ATP的降解，这一过程由26S蛋白酶体催化。
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