Coffino P
Department of Microbiology and Immunology and Department of Medicine, University of California, San Francisco, San Francisco, California 94143-0414, USA.
Nat Rev Mol Cell Biol. 2001 Mar;2(3):188-94. doi: 10.1038/35056508.
Proteins that are degraded by the proteasome are first modified by a set of enzymes that attach multiple copies of ubiquitin to substrate lysines, but a tiny minority, including the polyamine-synthesizing enzyme ornithine decarboxylase, is handled differently. This enzyme is targeted for destruction by another protein--antizyme. Why does ornithine decarboxylase have its own dedicated destruction mechanism, how does it work, and is it the only protein to be targeted to the proteasome in this way?
被蛋白酶体降解的蛋白质首先会被一组酶修饰，这些酶会将多个泛素分子连接到底物赖氨酸上，但一小部分蛋白质，包括多胺合成酶鸟氨酸脱羧酶，其处理方式有所不同。这种酶会被另一种蛋白质——抗酶靶向破坏。鸟氨酸脱羧酶为何拥有自己专门的破坏机制，它是如何工作的，以及它是否是唯一以这种方式被靶向蛋白酶体的蛋白质？
