Guillemard E, Geniteau-Legendre M, Kergot R, Lemaire G, Petit J F, Labarre C, Quero A M
Laboratoire de Virologie et Immunologie Expérimentales, Centre d'Etudes Pharmaceutiques de Châtenay-Malabry, France.
Antimicrob Agents Chemother. 1996 Apr;40(4):1057-9. doi: 10.1128/AAC.40.4.1057.
Nitric oxide (NO) generated by two NO donors (sodium nitroprusside or S-nitroso-L-glutathione) was shown to exert a dose-dependent inhibition of encephalomyocarditis virus growth in L-929 cells. This activity was not due to the cytotoxic or direct virucidal effects of NO donors. L-929 cells were shown to produce NO endogenously, but this low level of production did not counter encephalomyocarditis virus replication.
两种一氧化氮供体（硝普钠或S-亚硝基-L-谷胱甘肽）产生的一氧化氮（NO）对脑心肌炎病毒在L-929细胞中的生长具有剂量依赖性抑制作用。该活性并非由于一氧化氮供体的细胞毒性或直接杀病毒作用。研究表明L-929细胞可内源性产生NO，但这种低水平的产生并不能对抗脑心肌炎病毒的复制。
