Friede R L
J Neurol. 1979 May 2;220(3):149-56. doi: 10.1007/BF00705533.
Abnormal pigmentation was found in the striatum, pallidum and substantia nigra of two unrelated patients. Both had suffered from debilitating joint disease; there was no evidence of a progressive neurologic disorder. The pigment was localized in astrocytes and had the histochemical and electron microscopic features of melanin. The tissue changes suggest an anomaly of catecholamine metabolism either endogenous or induced by a still unknown exogenous factor.
在两名无血缘关系的患者的纹状体、苍白球和黑质中发现了色素沉着异常。两人均患有使人虚弱的关节疾病；没有进行性神经疾病的证据。色素定位于星形胶质细胞，具有黑色素的组织化学和电子显微镜特征。组织变化提示儿茶酚胺代谢异常，可能是内源性的，也可能是由一种尚不清楚的外源性因素诱发的。
