Galla J H, Schneider G, Kotchen T A, Hayslett J P
Endocrinology. 1977 Aug;101(2):389-95. doi: 10.1210/endo-101-2-389.
The renin-aldosterone system was studied in cardiomyopathic hamsters (CMH) before and after the onset of untreated clinical congestive heart failure. Age-matched random-bred hamsters (RB) served as controls. Before heart failure, there were no differences in body weight accretion, sodium balance, plasma renin activity or in vitro aldosterone production. After the onset of heart failure in CMH, body weight increased at a greater rate than in RB and positive sodium balance was nearly twice control levels. Although plasma renin activity was greater (P less than 0.005) in CMH than in RB (23.4+/-4.2 (mean+/-SEM) vs. 3.8+/-1.8 ng/ml/h), aldosterone production (101+/-15 vs. 95+/-16 ng/h) did not differ. Plasma aldosterone was low or undetectable in RB and in CMH in heart failure. In response to angiotensin stimulation, aldosterone production increased in both strains and did not differ. No difference in muscle potassium content, potassium balance or excretion was detected. Thus, in CMH, congestive heart failure is attended by increased plasma renin activity without a significant increase in aldosterone production, a dissociation which does not appear to be due to adrenal unresponsiveness to angiotensin II or to potassium depletion.
在未经治疗的临床充血性心力衰竭发作前后，对心肌病仓鼠（CMH）的肾素 - 醛固酮系统进行了研究。年龄匹配的随机繁殖仓鼠（RB）作为对照。在心力衰竭之前，体重增加、钠平衡、血浆肾素活性或体外醛固酮生成方面均无差异。CMH出现心力衰竭后，体重增加速度比RB更快，钠正平衡几乎是对照水平的两倍。尽管CMH中的血浆肾素活性高于RB（P小于0.005）（23.4±4.2（均值±标准误）对3.8±1.8 ng/ml/h），但醛固酮生成（101±15对95±16 ng/h）并无差异。RB以及处于心力衰竭状态的CMH中，血浆醛固酮水平较低或检测不到。对血管紧张素刺激的反应中，两种品系的醛固酮生成均增加且无差异。未检测到肌肉钾含量、钾平衡或排泄方面的差异。因此，在CMH中，充血性心力衰竭伴有血浆肾素活性增加，但醛固酮生成并未显著增加，这种分离现象似乎并非由于肾上腺对血管紧张素II无反应或钾缺乏所致。
